POLYMORPHISMS OF HPC2/ELAC2 AND SRD5A2 (5α-Reductase Type II) GENES IN PROSTATE CANCER

被引：3
|
作者：
Izmirli, M. [1 ]
Arikan, B. [2 ]
Bayazit, Y. [3 ]
Alptekin, D. [4 ]
机构：
[1] Bezmialem Vakif Univ, Dept Med Biol, Fac Med, TR-34093 Istanbul, Turkey
[2] Cukurova Univ, Dept Mol Biol, Fac Sci, Adana, Turkey
[3] Cukurova Univ, Dept Urol, Fac Med, Adana, Turkey
[4] Cukurova Univ, Dept Med Biol, Fac Med, Adana, Turkey
来源：
BALKAN JOURNAL OF MEDICAL GENETICS | 2011年 / 14卷 / 01期
关键词：
Prostate cancer; HPC2/ELAC2; gene; SRD5A2; Polymorphism; RISK; ASSOCIATION; VARIANTS; HEREDITARY; ONSET; CYP17;
D O I：
10.2478/v10034-011-0015-2
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Prostate cancer is the proliferation of malignant cells in the prostate gland. The HPC2/ELAC2 gene on chromosome 17p11.2 and SRD5A2 gene on chromosome 2p22-23 are predisposing genetic factors. We examined the relationship between Ser217Leu and Ala541Thr polymorphisms of the former gene, and Ala49Thr and Val89Leu polymorphisms of the latter gene to prostate cancer in Turkish men, using the polymerase chain reaction (PCR) method and appropriate restriction enzymes. The HPC2/ELAC2 gene Ser217Leu and SRD5A2 gene Ala49Thr polymorphisms were associated with an increased risk of prostate cancer in Turkish men [ for the HPC2/ELAC2 gene Ser217Leu polymorphism: odds ratio (OR) 2.7; confidence interval 95% (CI 95%) 1.6-4.8; p 0.000<0.05, and for the SRD5A2 gene Ala49Thr polymorphism: OR 2.4; CI 95% 1.2-4.9; p 0.004<0.05].
引用
收藏
页码：31 / 35
页数：5
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