PathExpress: a web-based tool to identify relevant pathways in gene expression data

被引：51
|
作者：
Goffard, Nicolas [1 ]
Weiller, Georg [1 ]
机构：
[1] Australian Natl Univ, Res Sch Biol Sci, Genom Interact Grp, ARC Ctr Excellence Integrat Legume Res & Bioinfor, Canberra, ACT 2601, Australia
来源：
NUCLEIC ACIDS RESEARCH | 2007年 / 35卷
基金：
澳大利亚研究理事会;
关键词：
D O I：
10.1093/nar/gkm261
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
PathExpress is a web-based tool developed to interpret gene expression data obtained from microarray experiments by identifying the most relevant metabolic pathways associated with a subset of genes (e. g. differentially expressed genes). A graphical pathway representation permits the visualization of the expressed genes in a functional context. Based on the publicly accessible KEGG Ligand database, PathExpress can be adapted to any organism and is currently available for seven Affymetrix genome arrays. About 20% of the probe sets of each array have been assigned to Enzyme Commission numbers by homology relationship and linked to corresponding metabolic pathways. PathExpress is available at http://bioinfoserver.rsbs.anu.edu.au/utils/PathExpress/.
引用
收藏
页码：W176 / W181
页数：6
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