Genetic and non-genetic mechanisms of inflammation may promote transformation in leukemia

被引：2
|
作者：
Vyas, Paresh [1 ]
机构：
[1] Univ Oxford, Oxford Biomed Res Ctr Hematol Theme, Oxford Ctr Haematol, Weatherall Inst Mol Med,MRC Mol Haematol Unit, Oxford, England
来源：
CELL STEM CELL | 2022年 / 29卷 / 02期
关键词：
CLONAL HEMATOPOIESIS; RISK;
D O I：
10.1016/j.stem.2022.01.006
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Non-genetic mechanisms of transformation are still relatively understudied and poorly understood. In this issue of Cell Stem Cell, Muto et al. provide preclinical evidence that loss of TRAF6 expression promotes transformation through a MYC-dependent mechanism that may be modulated by environmental inflammatory signals.
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页码：184 / 186
页数：3
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