Rejuvenating the blood and bone marrow to slow aging-associated cognitive decline and Alzheimer's disease

被引：11

作者：

Kang, Seokjo ^{[1
,2
]}

Moser, V. Alexandra ^{[1
,2
]}

Svendsen, Clive N. ^{[1
,2
]}

Goodridge, Helen S. ^{[1
,2
]}

机构：

[1] Cedars Sinai Med Ctr, Board Governors, Regenerat Med Inst, 8700 Beverly Blvd, Los Angeles, CA 90048 USA

[2] Cedars Sinai Med Ctr, Dept Biomed Sci, 8700 Beverly Blvd, Los Angeles, CA 90048 USA

来源：

COMMUNICATIONS BIOLOGY | 2020年 / 3卷 / 01期

关键词：

HEMATOPOIETIC STEM; PROGENITOR CELLS; PLASMA; BRAIN;

D O I：

10.1038/s42003-020-0797-4

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Parabiosis, blood exchange and plasma transfer experiments have highlighted the rejuvenating properties of young blood. Our Communications Biology study demonstrated that young bone marrow transplantation attenuates cognitive decline in old mice, with preservation of hippocampal synapses and reduced microglial reactivity. We now discuss subsequent studies that shed additional light on how blood impacts cognitive function, and potential clinical applications, including ongoing clinical trials with young plasma and experimental strategies targeting the hematopoietic system to slow or reverse cognitive decline.

引用

页数：4

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