Expression pattern of TG-interacting factor 2 during mouse development

被引：17
|
作者：
Jin, L
Zhou, YH
Kuang, CH
Lin, L
Chen, Y [1 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Shanghai 200031, Peoples R China
[2] Indiana Univ, Sch Med, Walther Oncol Ctr, Dept Med & Mol Genet, Indianapolis, IN 46202 USA
[3] Walther Canc Inst, Indianapolis, IN 46202 USA
来源：
GENE EXPRESSION PATTERNS | 2005年 / 5卷 / 04期
关键词：
TGIF2; TGIF; brain; development;
D O I：
10.1016/j.modep.2005.01.001
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
TGIF2 is a close homologue of TGIF that functions as a transcriptional corepressor by interaction with transforming growth factor-beta (TGF-beta)-activated Smads. Mutations of TGIF have been found in holoprosencephaly, a genetic disease affecting forebrain and craniofacial developmental. Here we analyzed the expression pattern of TGIF2 during mouse embryogenesis. Expression of TGIF2 transcripts was detected at high level at E12.5 and E15.5 in the nervous system including neopallial cortex, mesencephalon, metencephalon, medulla oblongata, spinal cord, trigemnal ganglion, vestibulocochlear ganglion and dorsal root ganglion. In addition, TGIF2 transcripts could be detected in other tissues including heart, lung, liver, pancreas, kidney, small intestine and nasal cavity. These data indicated that TGIF2 has a wide but well controlled expression pattern during mouse development. (c) 2005 Elsevier B.V. All rights reserved.
引用
收藏
页码：457 / 462
页数：6
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