Immunotherapy Approaches Targeting Regulatory T-Cells

被引：0
|
作者：
Onishi, Hideya [1 ]
Morisaki, Takashi [2 ]
Katano, Mitsuo [1 ]
机构：
[1] Kyushu Univ, Grad Sch Med Sci, Dept Canc Therapy & Res, Higashi Ku, Fukuoka 8128582, Japan
[2] Fukuoka Canc Gen Clin, Fukuoka, Japan
来源：
ANTICANCER RESEARCH | 2012年 / 32卷 / 03期
关键词：
Dendritic cells; CD4+T-cell; Treg; immunotherapy; regulatory T-cells; review; PERIPHERAL-BLOOD; CANCER PATIENTS; LUNG-CANCER; NKT CELLS; TGF-BETA; GAMMA; SUPPRESSION; EXPRESSION; PROGNOSIS; EXOSOMES;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The immune system prevents establishment and progression of cancer through innate and adaptive surveillance. However, some cancerous cells successfully evade the immune system. Regulatory, T-cells (Tregs) facilitate such evasion. Tregs may be the factor responsible for the limited success of human tumor immunotherapy to date. To improve immunotherapy, it is thought that the number of Tregs and their functions should be inhibited in patients with advanced cancer. In this review, we focus on recent immunotherapy efforts targeting Tregs.
引用
收藏
页码：997 / 1003
页数：7
相关论文
共 50 条
  • [31] Targeting regulatory T cells
    Sarah Crunkhorn
    Nature Reviews Drug Discovery, 2017, 16 (11) : 754 - 754
  • [32] Use of dendritic cells and CD4+ T-cells to expand γδ T-cells for immunotherapy
    Ye, Z
    Rich, IN
    Lamb, LS
    Harris, WG
    Lee, C
    Gee, AP
    Henslee-Downey, PJ
    EXPERIMENTAL HEMATOLOGY, 1998, 26 (08) : 743 - 743
  • [33] Regulatory T-cells and cord blood
    Blazar, BR
    BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2005, 11 (11) : 931 - 932
  • [34] Regulatory T-Cells against the Attack
    Krome, Susanne
    PNEUMOLOGIE, 2021, 75 (02):
  • [35] Multiple subsets of regulatory T-cells
    Kupriyanov, S., V
    Sinitsky, A., I
    Dolgushin, I. I.
    BYULLETEN SIBIRSKOY MEDITSINY, 2020, 19 (03): : 144 - 155
  • [36] Effector and regulatory T-cells in narcolepsy
    Lecendreux, M.
    Regnault, A.
    Franck, E.
    Klatzmann, D.
    Rosenzwajg, M.
    JOURNAL OF SLEEP RESEARCH, 2014, 23 : 295 - 296
  • [37] Peptide activated regulatory T-cells
    Stephen, J.
    Ward, F. J.
    Urbaniak, S. J.
    Barker, R. N.
    IMMUNOLOGY, 2007, 120 : 38 - 38
  • [38] Are regulatory T-cells linked with aging?
    Dejaco, Christian
    Duftner, Christina
    Schirmer, Michael
    EXPERIMENTAL GERONTOLOGY, 2006, 41 (04) : 339 - 345
  • [39] Role of regulatory T-cells in autoimmunity
    Mellanby, Richard J.
    Thomas, David C.
    Lamb, Jonathan
    CLINICAL SCIENCE, 2009, 116 (7-8) : 639 - 649
  • [40] Regulatory T-cells in alopecia areata
    Speiser, Jodi J.
    Mondo, Dana
    Mehta, Vikas
    Marcial, Sheela A.
    Kini, Ameet
    Hutchens, Kelli A.
    JOURNAL OF CUTANEOUS PATHOLOGY, 2019, 46 (09) : 653 - 658
12345