Rh-Catalyzed Direct Carboxylation of Alkenyl C-H Bonds of Alkenylpyrazoles

被引：15

作者：

Saitou, Takanobu ^{[1
]}

Jin, Yushu ^{[1
]}

Isobe, Kotaro ^{[1
]}

Suga, Takuya ^{[1
]}

Takaya, Jun ^{[1
]}

Iwasawa, Nobuharu ^{[1
]}

机构：

[1] Tokyo Inst Technol, Dept Chem, Meguro Ku, 2-12-1 O Okayama, Tokyo 1528551, Japan

来源：

CHEMISTRY-AN ASIAN JOURNAL | 2020年 / 15卷 / 13期

关键词：

carboxylation; alkenyl C-H activation; pyrazole; Rh(I) catalyst; TRANSITION-METAL-FREE; CARBON-DIOXIDE; MEDIATED CARBOXYLATION; CO2; PALLADIUM; CARBONYLATION; FUNCTIONALIZATION; ARYLPYRAZOLES; LACTONIZATION; ACTIVATION;

D O I：

10.1002/asia.202000476

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The Rh-catalyzed direct carboxylation of alkenyl C-H bonds was achieved by using pyrazole as a removable directing group. In the presence of 5 mol% RhCl3 . 3H(2)O, 6 mol% P(Mes)(3), and 2 equiv. of AlMe2(OMe), the alkenyl C-H bond of various alkenylpyrazoles was directly carboxylated in good yields under CO2 atmosphere. Furthermore, several useful transformations of the pyrazole moiety of the product were achieved to afford synthetically useful carboxylic acid derivatives in good yields.

引用

页码：1941 / 1944

页数：4

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