Synthesis and hybridization studies of oligonucleotide sequences with modified fluorescent nucleoside analogs

被引：0

作者：

Pandey, RK ^{[1
]}

Tripathi, S ^{[1
]}

Misra, K ^{[1
]}

机构：

[1] Univ Allahabad, Dept Chem, Nucl Acids Res Lab, Allahabad 211002, Uttar Pradesh, India

来源：

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 1998年 / 17卷 / 9-11期

关键词：

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two complementary oligodeoxynucleotide hexamers CATGAA and TTCATG and a pentamer with a fluorescent nucleoside analog viz. 9-N-(2'-deoxy-beta-D-ribofuranosyl) carbazole (C*) incorporated into it, TTC*ATG were synthesized and characterised by spectroscopic and chromatographic studies. The comparative fluorescent studies of the two nucleoside analogs viz. 9-N-(2'-deoxy-beta-D-ribofuranosyl) acridone and its carbazole analog (C*) have been carried out under different experimental conditions. The effect on fluorescence by incorporation of (C*) into the sequence and its subsequent hybridization with the complementary sequence have been studied.

引用

页码：1937 / 1948

页数：12

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