Miniature fluorescence molecular tomography (FMT) endoscope based on a MEMS scanning mirror and an optical fiberscope

被引：5

作者：

Yang, Hao ^{[1
]}

Wang, Dingkang ^{[2
]}

Shan, Tianqi ^{[3
]}

Dai, Xianjin ^{[3
]}

Xie, Huikai ^{[2
]}

Yang, Lily ^{[4
]}

Jiang, Huabei ^{[1
]}

机构：

[1] Univ S Florida, Dept Med Engn, Tampa, FL 33620 USA

[2] Univ Florida, Dept Elect & Comp Engn, Gainesville, FL USA

[3] Univ Florida, Dept Biomed Engn, Gainesville, FL USA

[4] Emory Univ, Dept Surg, Atlanta, GA 30322 USA

来源：

PHYSICS IN MEDICINE AND BIOLOGY | 2019年 / 64卷 / 12期

基金：

美国国家卫生研究院;

关键词：

fluorescence molecular tomography; endoscope; MEMS mirror; optical fiberscope; QUANTITATIVE FLUORESCENCE; PHOTOACOUSTIC TOMOGRAPHY; COHERENCE TOMOGRAPHY; PROBE; CANCER;

D O I：

10.1088/1361-6560/ab23b3

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

We present a novel FMT endoscope by using a MEMS scanning mirror and an optical fiberscope. The diameter of this highly miniaturized FMT device is only 5 mm. To our knowledge, this is the smallest FMT device we found so far. Several phantom experiments based on indocyanine green (ICG) were conducted to demonstrate the imaging ability of this device. Two tumor-bearing mice were systematically injected with tumor-targeted NIR fluorescent probes (ATF-PEG-IO-830) and were then imaged to further demonstrate the ability of this FMT endoscope for imaging small animals.

引用

页数：7

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