Pinocembrin Inhibits the Proliferation and Metastasis of Breast Cancer via Suppression of the PI3K/AKT Signaling Pathway

被引:17
|
作者
Zhu, Xinbing [1 ]
Li, Rongnian [2 ]
Wang, Chen [1 ]
Zhou, Shuo [1 ]
Fan, Yujia [1 ]
Ma, Shuang [1 ]
Gao, Didi [1 ]
Gai, Nian [1 ]
Yang, Jing [3 ]
机构
[1] Jinzhou Med Univ, Affiliated Hosp 1, Dept Breast Surg, Jinzhou, Peoples R China
[2] Panjin Liaohe Oilfield Gem Flower Hosp, Dept Gen Surg, Panjin, Peoples R China
[3] China Med Univ, Shengjing Hosp, Dept Otolaryngol Head & Neck Surg, Shenyang, Peoples R China
来源
FRONTIERS IN ONCOLOGY | 2021年 / 11卷
关键词
pinocembrin; breast cancer; cell cycle; apoptosis; PI3K/AKT signaling pathway; CELL-CYCLE ARREST; IN-VITRO; APOPTOSIS; EXTRACT; EXPRESSION; SURVIVIN; PTEN;
D O I
10.3389/fonc.2021.661184
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The survival rate of breast cancer (BC) patients remains poor, thus the identification of safe and effective new drugs is crucial to improve therapeutic outcomes and overall survival. Pinocembrin (PCB), a pharmacologically active ingredient of Pinus heartwood, Eucalyptus, Euphorbia, Populus, and Sparattosperma leucanthum, has been widely applied for the treatment of various diseases and possesses anticancer activities. In vitro assays were performed to investigate the antiproliferation and antimetastasis activities of PCB in BC cells. A tumorigenesis assay with the use of murine BC models was performed to assess the antiproliferation activities of PCB in vivo. Moreover, the molecular mechanisms underlying the anticancer activities of PCB in BC cells were explored. The results showed that the anti-inhibitory and antiproliferation activities of PCB in BC might involve cell cycle (G2/M phase) arrest and apoptosis. PCB downregulated the expression levels of proteins involved in cell cycle progression and apoptosis, including cyclinB1, Cdc2, PARP1, Bcl-2, and survivin, and upregulated protein levels of cleaved PARP1, cleaved caspase3, cleaved caspase9, and BAX. In a murine subcutaneous tumor model, PCB suppressed the growth of MCF-7 cells in vivo. Low concentrations of PCB also significantly inhibited the migration and invasion abilities of BC cells. Mechanistically, PCB administration was correlated to suppression of the PI3K/AKT signaling pathway. Inhibition of the proliferation of BC cells by PCB involved cell cycle (G2/M phase) arrest and apoptosis in vitro and in vivo. Low concentrations of PCB also significantly inhibited the migration and invasion abilities of BC cells. These findings suggest that PCB might be an effective agent for treatment of BC patients.
引用
下载
收藏
页数:13
相关论文
共 50 条
  • [11] Aclidinium inhibits proliferation and metastasis of ovarian cancer SKOV3 cells via downregulating PI3K/AKT/mTOR signaling pathway
    Qiao, Juan
    Wang, Wei-Jing
    Zhang, Yuan
    ONCOLOGY LETTERS, 2018, 16 (05) : 6417 - 6422
  • [12] ID2 Inhibits Bladder Cancer Progression and Metastasis via PI3K/AKT Signaling Pathway
    Mao, Weipu
    Wang, Keyi
    Sun, Si
    Wu, Jianping
    Chen, Ming
    Geng, Jiang
    Luo, Ming
    FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2021, 9
  • [13] Breast Cancer Invasion and Metastasis by mPRα Through the PI3K/Akt Signaling Pathway
    Wu, Xiaojuan
    Sun, Limin
    Wang, Xiao
    Su, Peng
    Li, Zhishuang
    Zhang, Chunyan
    Wang, Yan
    Gao, Peng
    Ma, Rong
    PATHOLOGY & ONCOLOGY RESEARCH, 2016, 22 (03) : 471 - 476
  • [14] UNBS5162 inhibits colon cancer growth via suppression of PI3K/Akt signaling pathway
    Zhang, Fan
    Lv, Hui-zeng
    Liu, Ji-ming
    Ye, Xiao-yong
    Wang, Cun-chuan
    M S-MEDECINE SCIENCES, 2018, 34 : 99 - 104
  • [15] NUCKS1 promotes breast cancer cell proliferation and metastasis via PI3K/AKT pathway
    Li, Song
    Wang, Daoliang
    TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH, 2022, 21 (10) : 2099 - 2105
  • [16] The PI3K/AKT/MTOR signaling pathway: The role of PI3K and AKT inhibitors in breast cancer
    Huemer F.
    Bartsch R.
    Gnant M.
    Current Breast Cancer Reports, 2014, 6 (2) : 59 - 70
  • [17] Amorphophalli Rhizoma inhibits breast cancer growth, proliferation, migration, and invasion via the PI3K/AKT pathway
    Li, Hailong
    Chen, Mingcang
    Yang, Zimei
    Xu, Chuchu
    Yu, Qinghong
    Song, Jiaqing
    Wang, Mengqian
    Gao, Xiufei
    JOURNAL OF ETHNOPHARMACOLOGY, 2022, 286
  • [18] Echinacoside inhibits colorectal cancer metastasis via modulating the gut microbiota and suppressing the PI3K/AKT signaling pathway
    Wei, Jiao
    Zheng, Zongmei
    Hou, Xinxin
    Jia, Fengjing
    Yuan, Yuan
    Yuan, Fuwen
    He, Feng
    Hu, Liang
    Zhao, Ling
    JOURNAL OF ETHNOPHARMACOLOGY, 2024, 318
  • [19] LAMC2 regulates the proliferation, invasion, and metastasis of gastric cancer via PI3K/Akt signaling pathway
    Cheng, Lulu
    Li, Xiaofei
    Dong, Wenhui
    Yang, Jing
    Li, Pengmei
    Qiang, Xihui
    Yin, Jiajun
    Guo, Lianyi
    JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 2024, 150 (05)
  • [20] Asiatic acid inhibits cervical cancer cell proliferation and migration via PI3K/AKT/mTOR signaling pathway
    Lin, Xiuying
    Fang, Yanqiu
    Mi, Xuguang
    Fu, Jianhua
    Chen, Shiling
    Wu, Mengxue
    Jin, Ningyi
    HELIYON, 2024, 10 (13)