Genetic propensity for obesity, socioeconomic position, and trajectories of body mass index in older adults

被引:6
|
作者
Tommerup, Kristiane [1 ]
Ajnakina, Olesya [1 ,2 ]
Steptoe, Andrew [1 ]
机构
[1] UCL, Inst Epidemiol & Hlth Care, Dept Behav Sci & Hlth, 1-19 Torrington Pl,Gower St, London, England
[2] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Biostat & Hlth Informat, London, England
基金
英国经济与社会研究理事会; 英国生物技术与生命科学研究理事会;
关键词
RISK; DEPRESSION; OVERWEIGHT; ACCURACY;
D O I
10.1038/s41598-021-99332-7
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Identifying how socioeconomic positioning and genetic factors interact in the development of obesity is imperative for population-level obesity prevention strategies. The current study investigated whether social positioning, either independently or through interaction with a polygenic score for Body Mass Index (BMI-PGS), influences BMI trajectories across older adulthood. Data were analysed from 7,183 individuals from the English Longitudinal Study of Aging (ELSA). Interactions between the BMI-PGS and; lower educational attainment, self-perceived social status (SSS), and income, on BMI trajectories over 12 years across older adulthood were investigated through linear mixed effects models. Lower educational attainment, SSS and income were each associated with a higher baseline BMI for women, but not for men. There were interaction effects between BMI-PGS and social positioning such that men aged > 65 with a lower educational attainment (beta = 0.62; 95%CI 0.00 - 1.24, p < 0.05), men aged <= 65 of a lower income (beta = - 0.72, 95%CI - 1.21 - - 0.23, p < 0.01) and women aged <= 65 of lower SSS (beta = - 1.41; 95%CI - 2.46 - 0.36, p < 0.01) showed stronger associations between the BMI-PGS and baseline BMI. There were few associations between markers of socioeconomic position and rate of change in BMI over the follow-up period. In sum, lower socioeconomic positioning showed adverse associations with women's BMI in older adulthood. Moreover, the expression of the BMI-PGS, or extent to which it translates to a higher BMI, was subtly influenced by socioeconomic standing in both women and in men.
引用
收藏
页数:11
相关论文
共 50 条
  • [31] Comparison of body mass index and bioimpedance for diagnosis of obesity in adults
    Karandish, Majid
    Mohammadi, Hamed
    Rasekhi, Hamid
    Sahebdel, Mahnoush
    Ghavami, Abed
    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2012, 27 : 311 - 311
  • [32] Incidence and predictors of fractures in older adults with and without obesity defined by body mass index versus body fat percentage
    Gandham, Anoohya
    Zengin, Ayse
    Bonham, Maxine P.
    Winzenberg, Tania
    Balogun, Saliu
    Wu, Feitong
    Aitken, Dawn
    Cicuttini, Flavia
    Ebeling, Peter R.
    Jones, Graeme
    Scott, David
    BONE, 2020, 140
  • [33] Body Mass Index Trajectories among Adolescents and Young Adults with CKD
    Parraga, Pierina P.
    Easterly, Caleb W.
    Filler, Guido
    Gilleskie, Donna B.
    Ferris, Maria E.
    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2024, 35 (10):
  • [34] Body mass index trajectories and functional decline in older adults: Three-City Dijon cohort study
    Artaud, Fanny
    Singh-Manoux, Archana
    Dugravot, Aline
    Tavernier, Beatrice
    Tzourio, Christophe
    Elbaz, Alexis
    EUROPEAN JOURNAL OF EPIDEMIOLOGY, 2016, 31 (01) : 73 - 83
  • [35] Body mass index trajectories and functional decline in older adults: Three-City Dijon cohort study
    Fanny Artaud
    Archana Singh-Manoux
    Aline Dugravot
    Béatrice Tavernier
    Christophe Tzourio
    Alexis Elbaz
    European Journal of Epidemiology, 2016, 31 : 73 - 83
  • [36] Incidence and predictors of fractures in older adults with and without obesity defined by body mass index versus body fat percentage
    Gandham, Anoohya
    Zengin, Ayse
    Bonham, Maxine P.
    Winzenberg, Tania
    Balogun, Saliu
    Wu, Feitong
    Aitken, Dawn
    Cicuttini, Flavia
    Ebeling, Peter R.
    Jones, Graeme
    Scott, David
    JOURNAL OF BONE AND MINERAL RESEARCH, 2020, 35 : 125 - 125
  • [37] Socioeconomic status and misperception of body mass index among Mexican adults
    Arantxa Colchero, M.
    Caro-Vega, Yanink
    Kaufer-Horwitz, Martha
    SALUD PUBLICA DE MEXICO, 2014, 56 (03): : 251 - 258
  • [38] Health Behaviours as Mediating Pathways between Socioeconomic Position and Body Mass Index
    Katja Borodulin
    Catherine Zimmer
    Risto Sippola
    Tomi E. Mäkinen
    Tiina Laatikainen
    Ritva Prättälä
    International Journal of Behavioral Medicine, 2012, 19 : 14 - 22
  • [39] Health Behaviours as Mediating Pathways between Socioeconomic Position and Body Mass Index
    Borodulin, Katja
    Zimmer, Catherine
    Sippola, Risto
    Makinen, Tomi E.
    Laatikainen, Tiina
    Prattala, Ritva
    INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE, 2012, 19 (01) : 14 - 22
  • [40] Informal caregiving and body mass index among older adults
    Jenkins, Kristi R.
    Kabeto, Mohammed U.
    Fultz, Nancy H.
    Langa, Kenneth M.
    JOURNAL OF GERONTOLOGICAL NURSING, 2007, 33 (04): : 42 - 51