Molecular analysis of the 2012 Bundibugyo virus disease outbreak

被引：4

作者：

Hulseberg, Christine E. ^{[1
]}

Kumar, Raina ^{[1
]}

Di Paola, Nicholas ^{[1
]}

Larson, Peter ^{[1
]}

Nagle, Elyse R. ^{[2
]}

Richardson, Joshua ^{[1
]}

Hanson, Jarod ^{[1
]}

Wauquier, Nadia ^{[3
,7
]}

Fair, Joseph N. ^{[3
,8
]}

Makuwa, Maria ^{[3
]}

Mulembakani, Prime ^{[3
]}

Muyembe-Tamfum, Jean-Jacques ^{[4
]}

Schoepp, Randal J. ^{[5
]}

Sanchez-Lockhart, Mariano ^{[1
]}

Palacios, Gustavo F. ^{[1
,9
]}

Kuhn, Jens H. ^{[6
]}

Kugelman, Jeffrey R. ^{[1
]}

机构：

[1] US Army, Med Res Inst Infect Dis, Ctr Genome Sci, Frederick, MD 21702 USA

[2] Natl Biodefense Anal & Countermeasures Ctr, Frederick, MD 21702 USA

[3] Metabiota Inc, Kinshasa, DEM REP CONGO

[4] Inst Natl Rech Biomed, Kinshasa, DEM REP CONGO

[5] US Army, Med Res Inst Infect Dis, Diagnost Syst Div, Frederick, MD 21702 USA

[6] NIAID, Integrated Res Facil Ft Detrick, NIH, Frederick, MD 21702 USA

[7] MRIGlobal, Dakar, Senegal

[8] Texas A&M, Scowcroft Inst, College Stn, TX 77840 USA

[9] Icahn Sch Med Mt Sinai, New York, NY 10029 USA

来源：

CELL REPORTS MEDICINE | 2021年 / 2卷 / 08期

基金：

美国国家卫生研究院;

关键词：

EBOLA-VIRUS; SEXUAL TRANSMISSION; UGANDA;

D O I：

10.1016/j.xcrm.2021.100351

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Bundibugyo virus (BDBV) is one of four ebolaviruses known to cause disease in humans. Bundibugyo virus disease (BVD) outbreaks occurred in 2007-2008 in Bundibugyo District, Uganda, and in 2012 in Isiro, Province Orientale, Democratic Republic of the Congo. The 2012 BVD outbreak resulted in 38 laboratory-confirmed cases of human infection, 13 of whom died. However, only 4 BDBV specimens from the 2012 outbreak have been sequenced, Here, we provide BDBV sequences from seven additional patients. Analysis of the molecular epidemiology and evolutionary dynamics of the 2012 outbreak with these additional isolates challenges the current hypothesis that the outbreak was the result of a single spillover event. In addition, one patient record indicates that BDBV's initial emergence in Isiro occurred 50 days earlier than previously accepted. Collectively, this work demonstrates how retrospective sequencing can be used to elucidate outbreak origins and provide epidemiological contexts to a medically relevant pathogen.

引用

页数：11

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