Promoter hypermethylation of Ras-related GTPase gene RRAD inactivates a tumor suppressor function in nasopharyngeal carcinoma

被引：43
|
作者：
Mo, Yingxi [1 ]
Midorikawa, Kaoru [1 ]
Zhang, Zhe [2 ]
Zhou, Xiaoying [2 ]
Ma, Ning [3 ]
Huang, Guangwu [2 ]
Hiraku, Yusuke [1 ]
Oikawa, Shinji [1 ]
Murata, Mariko [1 ]
机构：
[1] Mie Univ, Grad Sch Med, Dept Environm & Mol Med, Tsu, Mie, Japan
[2] Guangxi Med Univ, Affiliated Hosp 1, Dept Otolaryngol Head & Neck Surg, Nanning, Peoples R China
[3] Suzuka Univ Med Sci, Fac Hlth Sci, Matsusaka, Mie, Japan
来源：
CANCER LETTERS | 2012年 / 323卷 / 02期
关键词：
RRAD; Nasopharyngeal carcinoma; Methylation; ABERRANT METHYLATION; PATHOGENESIS; PROTEIN; MUSCLE; OVEREXPRESSION; GROWTH; CANCER; MEMBER; CELLS;
D O I：
10.1016/j.canlet.2012.03.042
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Nasopharyngeal carcinoma (NPC) is endemic in southern China. In a genome-wide screen for genes inactivated by promoter hypermethylation, we identified Ras-related associated with diabetes (RRAD). Expression of RRAD was down-regulated in 83.3% (30/36) of the biopsies from NPC patients. RRAD was aberrantly methylated in 74.3% (26/35) of primary tumors, but not in normal nasopharyngeal epithelium. Ectopic RRAD expression in NPC cell lines inhibited the cell growth, colony formation, and cell migration. These results indicate that RRAD might act as a functional tumor suppressor and its epigenetic inactivation may play an important role in NPC development. (c) 2012 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：147 / 154
页数：8
相关论文
共 50 条
  • [41] Detection of gene promoter hypermethylation in the tumor and serum of patients with gastric carcinoma
    Lee, TL
    Leung, WK
    Chan, MWY
    Ng, EKW
    Tong, JHM
    Lo, KW
    Chung, SCS
    Sung, JJY
    To, KF
    [J]. CLINICAL CANCER RESEARCH, 2002, 8 (06) : 1761 - 1766
  • [42] Tumor-suppressor Gene Promoter Hypermethylation in Saliva of Head and Neck Cancer Patients
    Ovchinnikov, Dmitry A.
    Cooper, Matthew A.
    Pandit, Pratibala
    Coman, William B.
    Cooper-White, Justin J.
    Keith, Patricia
    Wolvetang, Ernst J.
    Slowey, Paul D.
    Punyadeera, Chamindie
    [J]. TRANSLATIONAL ONCOLOGY, 2012, 5 (05): : 321 - 326
  • [43] Specific reversal of tumor-suppressor gene promoter hypermethylation with bovine oocyte extract
    Wang, Zhenfei
    Gao, Haixia
    Wang, Huimin
    Ren, Xiaolu
    Bao, Luri
    Sa, Rula
    Wang, Jie
    Bai, Haidong
    Yu, Haiquan
    [J]. ONCOLOGY REPORTS, 2013, 30 (01) : 179 - 184
  • [44] NOR1 is an HSF1-and NRF1-regulated putative tumor suppressor inactivated by promoter hypermethylation in nasopharyngeal carcinoma
    Li, Wenjuan
    Li, Xiaoling
    Wang, Wei
    Li, Xiayu
    Tan, Yixin
    Yi, Mei
    Yang, Jianbo
    McCarthy, James B.
    Xiong, Wei
    Wu, Minghua
    Ma, Jian
    Su, Bo
    Zhang, Zuping
    Liao, Qianjin
    Xiang, Bo
    Li, Guiyuan
    [J]. CARCINOGENESIS, 2011, 32 (09) : 1305 - 1314
  • [45] Promoter hypermethylation of the potential tumor suppressor DAL-1/4.1B gene in renal clear cell carcinoma
    Yamada, D
    Kikuchi, S
    Williams, YN
    Sakurai-Yageta, M
    Masuda, M
    Maruyama, T
    Tomita, K
    Gutmann, DH
    Kakizoe, T
    Kitamura, T
    Kanai, Y
    Murakami, Y
    [J]. INTERNATIONAL JOURNAL OF CANCER, 2006, 118 (04) : 916 - 923
  • [46] Promoter methylation status of the tumor suppressor gene SOX11 is associated with cell growth and invasion in nasopharyngeal carcinoma
    Song Zhang
    Shuo Li
    Jin-Liang Gao
    [J]. Cancer Cell International, 13
  • [47] Promoter methylation status of the tumor suppressor gene SOX11 is associated with cell growth and invasion in nasopharyngeal carcinoma
    Zhang, Song
    Li, Shuo
    Gao, Jin-Liang
    [J]. CANCER CELL INTERNATIONAL, 2013, 13
  • [48] Promoter Hypermethylation of Fibulin 1 Gene Is Associated With Tumor Progression in Hepatocellular Carcinoma
    Kanda, Mitsuro
    Nomoto, Shuji
    Okamura, Yukiyasu
    Hayashi, Masamichi
    Hishida, Mitsuhiro
    Fujii, Tsutomu
    Nishikawa, Yoko
    Sugimoto, Hiroyuki
    Takeda, Shin
    Nakao, Akimasa
    [J]. MOLECULAR CARCINOGENESIS, 2011, 50 (08) : 571 - 579
  • [49] CpG methylation inactivates the transcriptional activity of the promoter of the human p53 tumor suppressor gene
    Schroeder, M
    Mass, MJ
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1997, 235 (02) : 403 - 406
  • [50] Evaluation of promoter hypermethylation of tumor suppressor gene BRCA1 in epithelial ovarian cancer
    Das, Jhuma
    Chandra, Lal
    Gandhi, Gauri
    Amle, Dnyanesh B.
    Patnayak, Rachana L.
    Khurana, Nita
    Saxena, Alpana
    [J]. JOURNAL OF CANCER RESEARCH AND THERAPEUTICS, 2022, 18 (06) : 1578 - 1582
12345