Association of the chromosomal region 2q35 with type 1 diabetes mellitus in the Russian patients from Moscow

被引：0
|
作者：
Chernisheva, A. [1 ]
Tsitlidze, N. M. [1 ]
Savost'anov, K. V. [1 ]
Zil'berman, L. I. [2 ]
Kuraeva, T. L. [1 ,2 ]
Peterkova, V. A. [2 ]
Dedov, I. I. [2 ]
Nosikov, V. V. [1 ]
机构：
[1] State Res Inst Genet & Select Ind Microorganisms, Moscow 117545, Russia
[2] Russian Acad Med Sci, Endocrinol Res Ctr, Moscow 117036, Russia
来源：
RUSSIAN JOURNAL OF GENETICS | 2008年 / 44卷 / 02期
关键词：
D O I：
10.1134/S1022795408020117
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
To map human chromosome 2 region associated with type I diabetes mellitus, 89 families with concordant and discordant sib pairs were analyzed. Linkage and association with type I diabetes were examined using polymorphic microsatellite markers spanning the region of about 4 Mb. The linkage plot was constructed, and association of the five microsatellite markers within the chromosomal region 2q35 was examined. Polymorphic marker D2S137 (Z = 3.225, pc = 0.0048) demonstrated maximum linkage and association with type I diabetes.
引用
收藏
页码：193 / 196
页数：4
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