Oxidative and Nitrosative Stress Markers in Patients on Hemodialysis and Peritoneal Dialysis

被引:9
|
作者
Kose, Fadime Aydin [1 ]
Sezis, Meltem [2 ]
Akcicek, Fehmi [2 ]
Pabuccuoglu, Aysun [1 ]
机构
[1] Ege Univ, Dept Biochem, Fac Pharm, TR-35100 Izmir, Turkey
[2] Ege Univ, Dept Nephrol, Fac Med, TR-35100 Izmir, Turkey
关键词
Peritoneal dialysis; Hemodialysis; Oxidative stress; Nitrosative stress; Chronic renal failure; PROTEIN-TYROSINE NITRATION; GLUCOSE DEGRADATION-PRODUCTS; OXIDANT STRESS; MYELOPEROXIDASE; BIOCHEMISTRY; GLYCATION; NITROTYROSINE; CONSEQUENCES; DISEASE; DAMAGE;
D O I
10.1159/000328030
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Aim: The aim of this study was to evaluate the effects of hemodialysis (HD) and peritoneal dialysis (PD) treatments on oxidative and nitrosative stress markers comparatively. Methods: Twenty HD and 20 PD patients as well as 20 healthy individuals were included in this study. Plasma advanced oxidation protein products, myeloperoxidase, thiol group and 3-nitrotyrosine (3-NT) levels were measured in all subjects. Results: Plasma advanced oxidation protein products and myeloperoxidase levels were elevated by HD and PD treatments when compared to the control group. Conversely, plasma thiol group levels were decreased in HD and PD patients. 3-NT levels were increased by HD treatment only. Conclusions: The elevated plasma 3-NT levels in pre-HD and post-HD patients suggest that those patients have a considerably increased risk for nitrosative tissue injury. However, similar 3-NT levels of the control and PD groups support the advantage of PD therapy in terms of nitrosative tissue injury. Copyright (C) 2011 S. Karger AG, Basel
引用
收藏
页码:202 / 208
页数:7
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