Evaluation of oxidative and nitrosative stress in hemodialysis patients

Aim Oxidative/mtrosative stress has long been demonstrated in hemodialysis patients It is associated with numerous complications such as atherosclerosis and related cardio vascular disturbances However, the factors influencing oxidative/nitrosative status have not been characterized extensively in these patients Therefore, the present study was designed to investigate the alteration of oxidative/nitrosative stress parameters and total antioxidant status Methods Forty-one hemodialysis patients and 41 healthy subjects were enrolled in the present study Serum myeloperoxidase, nitrotyrosine and total antioxidant capacity were determined Results Serum myeloperoxidase and nitrotyrosine were significantly higher in the haemodialysis patients compared to the healthy subjects (P<0 05) while total antioxidant capacity was lower (P<0 01) Conclusion According to the results of this study, oxidative and nitrosative stress is increased in haemodialysis patients, therefore these alterations should be considered in the treatment of these patients