Is rTMS an Effective Therapeutic Strategy that Can Be Used to Treat Parkinson's Disease?

被引：13

作者：

Arias-Carrion, Oscar ^{[1
]}

Machado, Sergio ^{[2
,3
,4
,5
]}

Paes, Flavia ^{[2
,3
,6
]}

Velasques, Bruna ^{[4
,5
]}

Teixeira, Silmar ^{[5
]}

Cardenas-Morales, Lizbeth ^{[7
]}

Piedade, Roberto ^{[5
]}

Ribeiro, Pedro ^{[4
,5
,8
]}

Nardi, Antonio E. ^{[2
,3
]}

机构：

[1] Univ Marburg, Dept Neurol, D-35033 Marburg, Germany

[2] Univ Fed Rio de Janeiro, Pan & Respirat Lab, Inst Psychiat, Rio De Janeiro, Brazil

[3] Natl Inst Translat Med INCT TM, Rio De Janeiro, Brazil

[4] Inst Appl Neurosci INA, Rio De Janeiro, Brazil

[5] Univ Fed Rio de Janeiro, IPUB UFRJ, Inst Psychiat, BR-21941 Rio De Janeiro, Brazil

[6] Brazilian Inst Med & Rehabil IBMR, Fac Psychol, Rio De Janeiro, Brazil

[7] Univ Ulm, Dept Psychiat, D-89069 Ulm, Germany

[8] Biosci Dept EEFD UFRJ, Sch Phys Educ, Rio De Janeiro, Brazil

来源：

CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS | 2011年 / 10卷 / 06期

关键词：

rTMS; Parkinson's disease; cellular and molecular mechanisms; neurorehabilitation; sensorimotor integration; TRANSCRANIAL-MAGNETIC-STIMULATION; HUMAN MOTOR CORTEX; NONINVASIVE BRAIN-STIMULATION; LEVODOPA-INDUCED DYSKINESIAS; SINGLE-UNIT ACTIVITY; PREFRONTAL CORTEX; RAT-BRAIN; DOPAMINE RELEASE; HIGH-FREQUENCY; VISUAL-CORTEX;

D O I：

10.2174/187152711797247821

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive procedure whereby a pulsed magnetic field stimulates electrical activity in the brain. Parkinson's disease (PD) is a neurodegenerative process characterized by numerous motor and nonmotor clinical manifestations for which effective, mechanism-based treatments remain elusive. Consequently, more advanced non-invasive therapeutic methods are required. A possible method of rehabilitation that may be effective and potentially viable for use in clinical practice is rTMS. Here, we focus on the basic foundation of rTMS, the main findings of rTMS from animal models, the effects of rTMS on sensorimotor integration in patients with PD, and the experimental advances of rTMS that may become a viable clinical application to treat the disease.

引用

页码：693 / 702

页数：10

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