Sigma1 receptor antagonists attenuate antidepressant-like effect induced by co-administration of 1,3 Di-o-tolylguanidine (DTG) and memantine in the forced swimming test in rats

被引：0
|
作者：
Skuza, GY [1 ]
Rogóz, Z [1 ]
机构：
[1] Polish Acad Sci, Inst Pharmacol, Dept Pharmacol, PL-31343 Krakow, Poland
来源：
POLISH JOURNAL OF PHARMACOLOGY | 2003年 / 55卷 / 06期
关键词：
sigma ligands; DTG; memantine; synergistic effect; progesterone; BD; 1047; forced swimming test; rats;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The obtained results show that DTG, the sigma(1)/sigma(2) receptor agonist, exerts a synergistic effect with memantine, an uncompetitive NMDA receptor antagonist, in the forced swimming test in rats, and that progesterone and BD 1047, the sigma(1) receptor antagonists, counteract this effect. The results suggest that the sigma(1) receptor subtype may contribute to the behavioral response induced by combined administration of DTG and memantine in Porsolt's test in rats.
引用
收藏
页码：1149 / 1152
页数：4
相关论文
共 15 条
  • [11] Effects of combined administration of 5-HT1A or 5-HT1B receptor antagonists and antidepressant drugs in the forced swimming test in rats
    Tatarczynska, E
    Klodzinska, A
    Stachowicz, K
    Chojnacka-Wójcik, E
    EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2003, 13 : S197 - S198
  • [12] The antidepressant-like effect of 7-fluoro-1,3-diphenylisoquinoline-1-amine in the mouse forced swimming test is mediated by serotonergic and dopaminergic systems
    Pesarico, Ana Paula
    Sampaio, Tuane Bazanella
    Stangherlin, Eluza Curte
    Mantovani, Anderson C.
    Zeni, Gilson
    Nogueira, Cristina Wayne
    PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2014, 54 : 179 - 186
  • [13] Antidepressant-like effect of 1-methyl-1,2,3,4-tetrahydroisoquinoline in the rat forced swimming test: comparison with citalopram
    Wasik, A.
    Michaluk, J.
    Mozdzen, E.
    Romanska, I.
    Antkiewicz-Michaluk, L.
    EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2013, 23 : S422 - S423
  • [14] The neuropeptide Y (NPY) Y1 receptor subtype mediates NPY-induced antidepressant-like activity in the mouse forced swimming test
    Redrobe, JP
    Dumont, Y
    Fournier, A
    Quirion, R
    NEUROPSYCHOPHARMACOLOGY, 2002, 26 (05) : 615 - 624
  • [15] The Neuropeptide Y (NPY) Y1 Receptor Subtype Mediates NPY-induced Antidepressant-like Activity in the Mouse Forced Swimming Test
    John P Redrobe
    Yvan Dumont
    Alain Fournier
    Rémi Quirion
    Neuropsychopharmacology, 2002, 26 : 615 - 624
12