Two new cytotoxic clerodane diterpenoids from Casearia membranacea

被引：37
|
作者：
Shen, YC
Wang, LT
Wang, CH
Khalil, AT
Guh, JH
机构：
[1] Natl Sun Yat Sen Univ, Inst Marine Resources, Kaohsiung 80424, Taiwan
[2] Natl Taiwan Univ, Coll Med, Sch Pharm, Taipei, Taiwan
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 2004年 / 52卷 / 01期
关键词：
Flacourtiaccae; Casearia membranacea; clerodanes; cytotoxicity;
D O I：
10.1248/cpb.52.108
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
In addition to casearlucin A (3), two new clerodane diterpenes, caseamembrols A (1) and B (2) have been isolated from the leaves and twigs of Casearia membranacea by bioassay-guided fractionation. The structures of the new compounds were established on the basis of extensive 1D- and 2D-NMR spectroscopic analysis. Compounds 1-3 exhibited significant cytotoxicity against human prostate (PC-3) cancer cells.
引用
收藏
页码：108 / 110
页数：3
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