State-of-the-art genomics approaches in toxicology

被引：24

作者：

Van Hummelen, Paul ^{[1
,2
]}

Sasaki, Jennifer ^{[3
]}

机构：

[1] Univ Med & Dent New Jersey, BRTC, EOHSI, Piscataway, NJ 08854 USA

[2] VIB, MicroArray Facil, B-3000 Leuven, Belgium

[3] Johnson & Johnson Pharmaceut Res & Dev, Raritan, NJ 08869 USA

来源：

MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH | 2010年 / 705卷 / 03期

关键词：

Toxicogenomics; Transcriptomics; Toxicology; Genomics; Microarrays; GENE-EXPRESSION ANALYSIS; MICROARRAY DATA; PREDICTIVE TOXICOGENOMICS; NONGENOTOXIC CARCINOGENS; INDUCED HEPATOTOXICITY; IN-VITRO; REVEALS; IDENTIFICATION; SIGNATURES; PROFILES;

D O I：

10.1016/j.mrrev.2010.04.007

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Genomics may be an effective tool in decreasing the lengthy drug development process and reducing compound attrition. It can generate specific gene expression profiles induced by chemicals that can be linked to dose and response. Toxicogenomics can identify sensitive biomarkers of early deleterious effects, distinguish genotoxic from non-genotoxic carcinogens and can provide information on the mechanism of action. It can help bridge in vitro to in vivo findings and provide context for preclinical data and thus address human health risks. Issues and shortcomings that still need to be resolved or improved for efficient incorporation of genomics in drug development and environmental toxicology research include data analysis, data interpretation tools and accessible data repositories. In addition, implementation of toxicogenomics in early screening or drug discovery phases and effective use of this information by project teams remains a challenge. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：165 / 171

页数：7

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