Role of gap junctional intercellular communication (GJIC) through p38 and ERK1/2 pathway in the differentiation of rat neuronal stem cells

被引：13
|
作者：
Yang, SR
Cho, SD
Ahn, NS
Jung, JW
Park, JS
Jo, EH
Hwang, JW
Jung, JY
Kim, TY
Yoon, BS
Lee, BH
Kang, KS
Lee, YS
机构：
[1] Seoul Natl Univ, Coll Vet Med, Dept Vet Publ Hlth, Seoul 151742, South Korea
[2] Kyonggi Univ, Coll Nat Sci, Dept Biol, Genet Lab, Suwon 442760, South Korea
[3] Cheju Natl Univ, Coll Med, Inst Med Sci, Dept Anat & Neurobiol, Cheju 690756, South Korea
来源：
JOURNAL OF VETERINARY MEDICAL SCIENCE | 2005年 / 67卷 / 03期
关键词：
gap junctional intercellular communication; neuronal stem cell; PD98059 MEK inhibitor; rat; SB203580 p38 MAP kinase inhibitor;
D O I：
10.1292/jvms.67.291
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
Gap junctional intercellular communications (GJIC) contributes to neural function in development and differentiation of CNS. In this study, we have investigated the expression of GJIC during the differentiation of neuronal stem cells and 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced neuronal stem cell-derived cells from rat brain. During neuronal stem cell differentiation, expressions of Cx43 and 32 were increased for the duration of 72 hr, however the effect were decreased on the 7d. In the neuronal stem cell-derived cells, pretreatments with p38 MAP kinase inhibitor, SB203580, and MEK inhibitor, PD98059, could protect GJIC against TPA-induced inhibition of GJIC. Our data suggest that GJIC plays an important role during neuronal stem cell differentiation, and ERK1/2 and p38 MAP kinase signaling pathway may be closely related functionally to regulate gap junction in rat neuronal stem cell-derived cells.
引用
收藏
页码：291 / 294
页数：4
相关论文
共 50 条
  • [31] Ghrelin induces cardiac lineage differentiation of human embryonic stem cells through ERK1/2 pathway
    Gao, Meijuan
    Yang, Jin
    Wei, Rui
    Liu, Guoqiang
    Zhang, Lin
    Wang, Haining
    Wang, Guang
    Gao, Hongwei
    Chen, Guian
    Hong, Tianpei
    INTERNATIONAL JOURNAL OF CARDIOLOGY, 2013, 167 (06) : 2724 - 2733
  • [32] Ghrelin accelerates the growth and osteogenic differentiation of rabbit mesenchymal stem cells through the ERK1/2 pathway
    Ye, Nan
    Jiang, Dianming
    BMC BIOTECHNOLOGY, 2015, 15
  • [33] Ghrelin accelerates the growth and osteogenic differentiation of rabbit mesenchymal stem cells through the ERK1/2 pathway
    Nan Ye
    Dianming Jiang
    BMC Biotechnology, 15
  • [34] Involvement of ERK1/2, p38 and PI3K in megakaryocytic differentiation of K562 cells
    Conde, Isabel
    Pabon, Dina
    Jayo, Asier
    Lastres, Pedro
    Gonzalez-Manchon, Consuelo
    EUROPEAN JOURNAL OF HAEMATOLOGY, 2010, 84 (05) : 430 - 440
  • [35] Involvement of ERK1/2 and p38 in mediating Mg2+uptake in liver cells
    Cefaratti, C
    Torres, L
    Romani, A
    FASEB JOURNAL, 2005, 19 (05): : A1165 - A1165
  • [36] PP2 Regulates Human Trophoblast Cells Differentiation by Activating p38 and ERK1/2 and Inhibiting FAK Activation
    Daoud, G.
    Le Bellego, F.
    Lafond, J.
    PLACENTA, 2008, 29 (10) : 862 - 870
  • [37] Peculiarities of the Involvement of MAPKS ERK1/2 and p38 in the Implementation of the Functions of Neural Stem Cells and Neuronal Committed Precursors in Ethanol-Induced Neurodegeneration
    Zyuz'kov, G. N.
    Miroshnichenko, L. A.
    Polyakova, T. Yu.
    Stavrova, L. A.
    Simanina, E. V.
    Zhdanov, V. V.
    Chaikovskii, A. V.
    BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2020, 169 (05) : 609 - 613
  • [38] Topical dihydroartemisinin inhibits suture-induced neovascularization in rat corneas through ERK1/2 and p38 pathways
    Yan-Yan Zhong 1
    International Journal of Ophthalmology, 2011, (02) : 150 - 155
  • [39] A comparison of the involvement of p38, ERK1/2 and PI3K in growth factor-induced chondrogenic differentiation of mesenchymal stem cells
    McMahon, Louise A.
    Prendergast, Patrick J.
    Campbell, Veronica A.
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2008, 368 (04) : 990 - 995
  • [40] The Role of MARK ERK1/2 and p38 in Regulation of Functions of Neural Stem Cells and Neuroglia under Conditions of β-Amyloid-Induced Neurodegeneration
    Zyuz'kov, G. N.
    Miroshnichenko, L. A.
    Chaikovsky, A. V.
    Kotlovskaya, L. Yu.
    BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2022, 173 (04) : 424 - 428
12345