Role of gap junctional intercellular communication (GJIC) through p38 and ERK1/2 pathway in the differentiation of rat neuronal stem cells

被引：13
|
作者：
Yang, SR
Cho, SD
Ahn, NS
Jung, JW
Park, JS
Jo, EH
Hwang, JW
Jung, JY
Kim, TY
Yoon, BS
Lee, BH
Kang, KS
Lee, YS
机构：
[1] Seoul Natl Univ, Coll Vet Med, Dept Vet Publ Hlth, Seoul 151742, South Korea
[2] Kyonggi Univ, Coll Nat Sci, Dept Biol, Genet Lab, Suwon 442760, South Korea
[3] Cheju Natl Univ, Coll Med, Inst Med Sci, Dept Anat & Neurobiol, Cheju 690756, South Korea
来源：
JOURNAL OF VETERINARY MEDICAL SCIENCE | 2005年 / 67卷 / 03期
关键词：
gap junctional intercellular communication; neuronal stem cell; PD98059 MEK inhibitor; rat; SB203580 p38 MAP kinase inhibitor;
D O I：
10.1292/jvms.67.291
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
Gap junctional intercellular communications (GJIC) contributes to neural function in development and differentiation of CNS. In this study, we have investigated the expression of GJIC during the differentiation of neuronal stem cells and 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced neuronal stem cell-derived cells from rat brain. During neuronal stem cell differentiation, expressions of Cx43 and 32 were increased for the duration of 72 hr, however the effect were decreased on the 7d. In the neuronal stem cell-derived cells, pretreatments with p38 MAP kinase inhibitor, SB203580, and MEK inhibitor, PD98059, could protect GJIC against TPA-induced inhibition of GJIC. Our data suggest that GJIC plays an important role during neuronal stem cell differentiation, and ERK1/2 and p38 MAP kinase signaling pathway may be closely related functionally to regulate gap junction in rat neuronal stem cell-derived cells.
引用
收藏
页码：291 / 294
页数：4
相关论文
共 50 条
  • [1] The roles of ERK1/2 and p38 MAP kinases in the preventive mechanisms of mushroom Phellinus linteus against the inhibition of gap junctional intercellular communication by hydrogen peroxide
    Cho, JH
    Cho, SD
    Hu, HB
    Kim, SH
    Lee, SK
    Lee, YS
    Kang, KS
    CARCINOGENESIS, 2002, 23 (07) : 1163 - 1169
  • [2] A regulatory role for p38δ MAPK in keratinocyte differentiation -: Evidence for p38δ-ERK1/2 complex formation
    Efimova, T
    Broome, AM
    Eckert, RL
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (36) : 34277 - 34285
  • [3] Differential effects of p38 and Erk1/2 on the chondrogenic and osteogenic differentiation of dental pulp stem cells
    Ba, Pengfei
    Duan, Xiaoyu
    Fu, Guo
    Lv, Shuyan
    Yang, Pishan
    Sun, Qinfeng
    MOLECULAR MEDICINE REPORTS, 2017, 16 (01) : 63 - 68
  • [4] Chinese cabbage extracts and sulforaphane can protect H2O2-induced inhibition of gap junctional intercellular communication through the inactivation of ERK1/2 and p38 MAP kinases
    Hwang, JW
    Park, JS
    Jo, EH
    Kim, SJ
    Yoon, BS
    Kim, SH
    Lee, YS
    Kang, KS
    JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2005, 53 (21) : 8205 - 8210
  • [5] Anisomycin downregulates gap-junctional intercellular communication via the p38 MAP-kinase pathway
    Ogawa, T
    Hayashi, T
    Kyoizumi, S
    Kusunoki, Y
    Nakachi, K
    MacPhee, DG
    Trosko, JE
    Kataoka, K
    Yorioka, N
    JOURNAL OF CELL SCIENCE, 2004, 117 (10) : 2087 - 2096
  • [6] αCGRP Regulates Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells Through ERK1/2 and p38 MAPK Signaling Pathways
    Jiang, Yixuan
    Xin, Na
    Xiong, Yi
    Guo, Yanjun
    Yuan, Ying
    Zhang, Qin
    Gong, Ping
    CELL TRANSPLANTATION, 2022, 31
  • [7] Sesamin stimulates osteoblast differentiation through p38 and ERK1/2 MAPK signaling pathways
    Wanachewin, Orawan
    Boonmaleerat, Kanchanit
    Pothacharoen, Peraphan
    Reutrakul, Vichai
    Kongtawelert, Prachya
    BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2012, 12
  • [8] Sesamin stimulates osteoblast differentiation through p38 and ERK1/2 MAPK signaling pathways
    Orawan Wanachewin
    Kanchanit Boonmaleerat
    Peraphan Pothacharoen
    Vichai Reutrakul
    Prachya Kongtawelert
    BMC Complementary and Alternative Medicine, 12
  • [9] The mapk pathway and sexual differentiation: effects of inhibitors of p38 mapk and erk1/erk2 in the developing gonad
    Paranjpe, Monika
    Renfree, Marilyn
    Shaw, Geoff
    Pask, Andrew
    Yu, Hongshi
    CLINICAL ENDOCRINOLOGY, 2017, 86 : 31 - 32
  • [10] ERK1/2 and p38 regulate trophoblasts differentiation in human term placenta
    Daoud, G
    Amyot, M
    Rassart, É
    Masse, A
    Simoneau, L
    Lafond, J
    JOURNAL OF PHYSIOLOGY-LONDON, 2005, 566 (02): : 409 - 423
12345