Mitochondrial Apoptotic Priming Is Associated with Clinical Response to the Bcl-2 Antagonist ABT-199 in Chronic Lymphocytic Leukemia

被引:0
|
作者
Davids, Matthew S. [1 ]
Deng, Jing [1 ]
Ryan, Jeremy [1 ]
Fernandes, Stacey M. [1 ]
Brown, Jennifer R. [1 ]
Letai, Anthony G. [1 ]
机构
[1] Dana Farber Canc Inst, Boston, MA 02115 USA
关键词
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页数:3
相关论文
共 50 条
  • [21] Integrated Stress Response Activation Induced By Usnic Acid Alleviates BCL-2 Inhibitor ABT-199 Resistance in Acute Myeloid Leukemia
    Li, Man
    Dong, Jingjie
    Hong, Yaonan
    Jin, Li
    Sun, Chengtao
    Liu, Qi
    Li, Liqin
    Han, Xiaoxiao
    Deng, Shengqian
    Feng, Yue
    Shen, Yiping
    Kai, Guoyin
    Wu, Dijiong
    BLOOD, 2024, 144 : 4158 - 4159
  • [22] Correlative biomarkers of clinical activity of the BCL-2 inhibitor, venetoclax (ABT-199/GDC-0199), in acute myeloid leukemia patients
    Popovic, Relja
    Daver, Naval
    Ruvolo, Vivian
    Chen, Ken
    Wang, Zixing
    Huang, Xin
    Mabry, Mack
    Potluri, Jalaja
    McKeegan, Evelyn
    Konopleva, Marina
    Chyla, Brenda J.
    CANCER RESEARCH, 2016, 76
  • [23] Quantitative assessment of BCL-2: BIM complexes as a pharmacodynamic marker for venetoclax (ABT-199)
    Jin, Sha
    Tapang, Paul
    Osterling, Donald J.
    Gao, Wenqing
    Albert, Daniel H.
    Souers, Andrew J.
    Leverson, Joel D.
    Phillips, Darren C.
    Chen, Jun
    CANCER RESEARCH, 2015, 75
  • [24] THE BCL-2 INHIBITOR ABT-199 (GDC-0199) IS ACTIVE AND WELL-TOLERATED IN ULTRA HIGH-RISK RELAPSED/REFRACTORY CHRONIC LYMPHOCYTIC LEUKEMIA (CLL)
    Roberts, A.
    Davids, M.
    Pagel, J.
    Kahl, B.
    Wierda, W.
    Miller, T.
    Gerecitano, J.
    Kipps, T.
    Anderson, M.
    Huang, D.
    Darden, D.
    Gressick, L.
    Nolan, C.
    Yang, J.
    Busman, T.
    Graham, A.
    Cerri, E.
    Enschede, S.
    Humerickhouse, R.
    Seymour, J.
    HAEMATOLOGICA, 2013, 98 : 473 - 473
  • [25] BCL-2 Antagonist ABT-199 Combined with Complex I Inhibitor IACS-010759 Blocks Mitochondrial Respiration and Facilitates Anti-Leukemia Efficacy in Pre-Clinical AML Models
    Zhang, Qi
    Han, Lina
    Cai, Tianyu
    Kuruvilla, Vinitha Mary
    Cavazos, Antonio
    Ma, Helen
    Battula, Venkata Lokesh
    Baran, Natalia
    Harutyunyan, Karine
    Andreeff, Michael
    Tabe, Yoko
    Marszalek, Joseph R.
    Konopleva, Marina
    BLOOD, 2017, 130
  • [26] Dexamethasone Synergizes with ABT-199 through the Induction of Bim and Bcl-2 Dependence in Myeloma
    Matulis, Shannon
    Nooka, Ajay K.
    Von Hollen, Hayley
    Kaufman, Jonathan L.
    Lonial, Sagar
    Boise, Lawrence H.
    BLOOD, 2014, 124 (21)
  • [27] Bcl-2 phosphorylation confers resistance on chronic lymphocytic leukaemia cells to the BH3 mimetics ABT-737, ABT-263 and ABT-199 by impeding direct binding
    Song, Ting
    Chai, Gaobo
    Liu, Yubo
    Yu, Xiaoyan
    Wang, Ziqian
    Zhang, Zhichao
    BRITISH JOURNAL OF PHARMACOLOGY, 2016, 173 (03) : 471 - 483
  • [28] The BCL-2 inhibitor ABT-199/venetoclax synergizes with proteasome inhibition via transactivation of the MCL-1 antagonist NOXA
    Weller, Sandra
    Toenniessen, Astrid
    Schaefer, Benjamin
    Beigl, Tobias
    Muenchow, Alina
    Bopple, Kathrin
    Hofmann, Ute
    Gillissen, Bernhard F.
    Aulitzky, Walter E.
    Kopp, Hans-Georg
    Essmann, Frank
    CELL DEATH DISCOVERY, 2022, 8 (01)
  • [29] Evaluation of the Bcl-2 inhibitor ABT-199 in xenograft models of acute lymphoblastic leukemia by the pediatric preclinical testing program
    Suryani, Santi
    Evans, Kathryn
    Richmond, Jennifer
    Robbins, Alissa
    Bracken, Lauryn
    Kurmasheva, Raushan
    Houghton, Peter J.
    Smith, Malcolm A.
    Lock, Richard B.
    CANCER RESEARCH, 2015, 75
  • [30] ABT-199 mediated inhibition of BCL-2 as a novel therapeutic strategy in T-cell acute lymphoblastic leukemia
    Peirs, Sofie
    Matthijssens, Filip
    Goossens, Steven
    Van de Walle, Inge
    Ruggero, Katia
    de Bock, Charles E.
    Degryse, Sandrine
    Cante-Barrett, Kirsten
    Briot, Delphine
    Clappier, Emmanuelle
    Lammens, Tim
    De Moerloose, Barbara
    Benoit, Yves
    Poppe, Bruce
    Meijerink, Jules P.
    Cools, Jan
    Soulier, Jean
    Rabbitts, Terence H.
    Taghon, Tom
    Speleman, Frank
    Van Vlierberghe, Pieter
    BLOOD, 2014, 124 (25) : 3738 - 3747