Lewis Base-Catalyzed One-Pot Cascade Sequences of O-Alkenyl-Substituted Cyanohydrins: Diastereoselective Synthesis of Multisubstituted Dihydrofurans

被引：8

作者：

Du, Shan-Tao ^{[1
]}

Sun, Zhen ^{[1
]}

Liu, Wei ^{[1
]}

Liao, Wei-Wei ^{[1
]}

机构：

[1] Jilin Univ, Coll Chem, 2699 Qianjin St, Changchun 130012, Jilin, Peoples R China

来源：

ORGANIC LETTERS | 2017年 / 19卷 / 24期

关键词：

QUATERNARY CARBON CENTERS; FREE INTRAMOLECULAR CARBOCYANATION; ORGANOCATALYTIC DOMINO REACTIONS; ASYMMETRIC-SYNTHESIS; ACTIVATED ALKENES; ENANTIOSELECTIVE SYNTHESIS; ORGANIC-SYNTHESIS; CONSTRUCTION; 2,3-DIHYDROBENZOFURANS; ACYLCYANATION;

D O I：

10.1021/acs.orglett.7b03301

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first example of the diastereoselective construction of polysubstituted 2,3-dihydrofurans incorporating contiguous quaternary and tertiary carbon centers via a Lewis base-catalyzed one-pot cascade sequence is described. The diversity and complexity of the final products can be efficiently constructed with high diastereoselectivities via this catalytic multistep process under mild reaction conditions.

引用

页码：6598 / 6601

页数：4

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