Evaluation of microvessel density and p53 expression in pancreatic adenocarcinoma

被引：7

作者：

Jureidini, Ricardo ^{[1
]}

Monteiro da Cunha, Jose Eduardo ^{[1
]}

Takeda, Flavio ^{[1
]}

Namur, Guilherme Naccache ^{[1
]}

Ribeiro, Thiago Costa ^{[1
]}

Patzina, Rosely ^{[2
]}

Figueira, Estela R. R. ^{[1
]}

Ribeiro, Ulysses, Jr. ^{[1
]}

Bacchella, Telesforo ^{[1
]}

Cecconello, Ivan ^{[1
]}

机构：

[1] Univ Sao Paulo, Fac Med, Dept Gastroenterol, Sao Paulo, SP, Brazil

[2] Univ Sao Paulo, Fac Med, Dept Patol, Sao Paulo, SP, Brazil

来源：

Clinics | 2016年 / 71卷 / 06期

关键词：

Pancreatic Neoplasms; Molecular Biology; p53; protein; Prognosis; Microvessel; ENDOTHELIAL GROWTH-FACTOR; TUMOR ANGIOGENESIS; CANCER; STATISTICS; SURVIVAL;

D O I：

10.6061/clinics/2016(06)05

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

OBJECTIVE: To evaluate the prognostic significance of microvessel density and p53 expression in pancreatic cancer. METHODS: Between 2008 and 2012, 49 patients with pancreatic adenocarcinoma underwent resection with curative intention. The resected specimens were immunohistochemically stained with anti-p53 and anti-CD34 antibodies. Microvessel density was assessed by counting vessels within ten areas of each tumoral section a highpower microscope. RESULTS: The microvessel density ranged from 21.2 to 54.2 vessels/mm(2). Positive nuclear staining for p53 was found in 20 patients (40.6%). The overall median survival rate after resection was 24.1 months and there were no differences in survival rates related to microvessel density or p53 positivity. Microvessel density was associated with tumor diameter greater than 3.0 cm and with R0 resection failure. CONCLUSIONS: Microvessel density was associated with R1 resection and with larger tumors. p53 expression was not correlated with intratumoral microvessel density in pancreatic adenocarcinoma.

引用

页码：315 / 319

页数：5

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