Gap junction protein Innexin2 modulates the period of free-running rhythms in Drosophila melanogaster

被引：2

作者：

Ramakrishnan, Aishwarya ^{[1
]}

Sheeba, Vasu ^{[1
]}

机构：

[1] Jawaharlal Nehru Ctr Adv Sci Res, Neurosci Unit, Chronobiol & Behav Neurogenet Lab, Bangalore 560064, Karnataka, India

来源：

ISCIENCE | 2021年 / 24卷 / 09期

关键词：

ELECTRICAL SYNAPSES; PACEMAKER NEURONS; CIRCADIAN CLOCK; BEHAVIORAL RHYTHMS; ACCESSORY MEDULLA; CELLS; PDF; NETWORK; GENE; COMMUNICATION;

D O I：

10.1016/j.isci.2021.103011

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A neuronal circuit of similar to 150 neurons modulates rhythmic activity-rest behavior of Drosophila melanogaster. While it is known that coherent similar to 24-hr rhythms in locomotion are brought aboutwhen 7 distinct neuronal clusters function as a network due to chemical communication amongst them, there are no reports of communication via electrical synapses made up of gap junctions. Here, we report that gap junction proteins, Innexins play crucial roles in determining the intrinsic period of activity-rest rhythms in flies. We show the presence of Innexin2 in the ventral lateral neurons, wherein RNAi-based knockdown of its expression slows down the speed of activity-rest rhythm along with alterations in the oscillation of a core- clock protein PERIOD and the output molecule pigment dispersing factor. Specifically disrupting the channel-forming ability of Innexin2 causes period lengthening, suggesting that Innexin2 may function as hemichannels or gap junctions in the clock circuit.

引用

页数：22