Synthesis and evaluation of Mannich bases of β-resorcylic acid for antinflammatory and antimicrobial properties

被引:0
|
作者
Mishra, A [1 ]
Kanth, MSV [1 ]
机构
[1] Sch Pharm, Dept Pharm, Indore 452017, India
关键词
synthesis; Mannich base; beta-resorcylic acid; antiinflammatory and antimicrobial properties;
D O I
暂无
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Mannich bases of beta-resorcylic acid were synthesized using different secondary amines. They were characterized by analytical and spectral analysis. Antiinflammatory and antimicrobial activity of synthesized compounds was evaluated and some compounds showed greater anti-inflammatory activity when compared to parent compound. Almost all compounds showed antimicrobial activity against tested organisms.
引用
收藏
页码:1231 / 1234
页数:4
相关论文
共 50 条
  • [31] Synthesis of some new 1,2,4-triazoles, their Mannich and Schiff bases and evaluation of their antimicrobial activities
    Bayrak, Hacer
    Demirbas, Ahmet
    Karaoglu, Senguel Alpay
    Demirbas, Neslihan
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2009, 44 (03) : 1057 - 1066
  • [32] Synthesis and Characterisation of Flavonoid Mannich Bases and the Evaluation of their Cytotoxic Activity
    Chang, Chew-Cheen
    Sim, Kooi-Mow
    Lim, Tuck-Meng
    Pichika, Mallikarjuna Rao
    Mak, Kit- Kay
    LETTERS IN ORGANIC CHEMISTRY, 2024, 21 (01) : 77 - 88
  • [33] Synthesis of Mannich bases of some 2,5-disubstituted 4-thiazolidinones and evaluation of their antimicrobial activities
    Altintas, H
    Ates, O
    Birteksöz, S
    Ötük, G
    Uzun, M
    Satana, D
    TURKISH JOURNAL OF CHEMISTRY, 2005, 29 (04) : 425 - 435
  • [34] New N-Mannich bases obtained from isatin and piperazine derivatives: the synthesis and evaluation of antimicrobial activity
    Bogdanov, Andrei V.
    Vazykhova, Al'bina M.
    Khasiyatullina, Nadezhda R.
    Krivolapov, Dmitry B.
    Dobrynin, Alexey B.
    Voloshina, Alexandra D.
    Mironov, Vladimir F.
    CHEMISTRY OF HETEROCYCLIC COMPOUNDS, 2016, 52 (01) : 25 - 30
  • [35] Synthesis of Mannich bases of some 2,5-disubstituted 4-thiazolidinones and evaluation of their antimicrobial activities
    Kocabalkanli, A
    Ates, Ö
    Ötük, G
    ARCHIV DER PHARMAZIE, 2001, 334 (02) : 35 - 39
  • [36] Synthesis and pharmacological evaluation of clubbed isopropylthiazole derived triazolothiadiazoles, triazolothiadiazines and mannich bases as potential antimicrobial and antitubercular agents
    Kumar, G. V. Suresh
    Prasad, Y. Rajendra
    Mallikarjuna, B. P.
    Chandrashekar, S. M.
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2010, 45 (11) : 5120 - 5129
  • [37] EVALUATION OF ANTIMICROBIAL ACTIVITY AND QSAR STUDY OF A MOLECULE LIBRARY OF THE MANNICH BASES OF GLUTARIMIDES
    Das Manikpuri, A.
    Joshi, Sh.
    OXIDATION COMMUNICATIONS, 2013, 36 (01): : 156 - 175
  • [38] Synthesis and in-vitro cytotoxicity evaluation of Gatifloxacin Mannich bases
    Yogeeswari, P
    Sriram, D
    Kavya, R
    Tiwari, S
    BIOMEDICINE & PHARMACOTHERAPY, 2005, 59 (09) : 501 - 510
  • [39] Synthesis and Biological Evaluation of Some Mannich Bases of Benzothiazolyl Oxadiazoles
    Rajeeva, B.
    Yadav, Sanjay Kumar
    Shantakumar, S. M.
    ASIAN JOURNAL OF CHEMISTRY, 2009, 21 (06) : 4339 - 4345
  • [40] New N-Mannich bases obtained from isatin and piperazine derivatives: the synthesis and evaluation of antimicrobial activity
    Andrei V. Bogdanov
    Al’bina M. Vazykhova
    Nadezhda R. Khasiyatullina
    Dmitry B. Krivolapov
    Alexey B. Dobrynin
    Alexandra D. Voloshina
    Vladimir F. Mironov
    Chemistry of Heterocyclic Compounds, 2016, 52 : 25 - 30