Ketogenic diet does not disturb neurogenesis in the dentate gyrus in rats

被引：10
|
作者：
Strandberg, Joakim [1 ]
Kondziella, Daniel [1 ]
Thorlin, Torleif [1 ]
Asztely, Fredrik [1 ]
机构：
[1] Sahlgrens Acad, Inst Clin Neurosci & Rehabil, Epilepsy Res Grp, SE-41345 Gothenburg, Sweden
来源：
NEUROREPORT | 2008年 / 19卷 / 12期
关键词：
bromodeoxyuridine; epilepsy; hippocampus; ketogenic diet; neurogenesis; treatment;
D O I：
10.1097/WNR.0b013e32830a7109
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The ketogenic diet, a high-fat diet, is a therapeutic alternative in the treatment of refractory epilepsy, especially in children. However, there are concerns that a high-fat diet may influence the normal development of the central nervous system and cognition. In this study we investigated the influence of ketogenic diet on adult neurogenesis in the dentate gyrus. Rats were provided with either a high-fat diet (80% fat) or a standard rat diet (5% fat) ad libitum for 4 weeks. In both female and male rats, the amounts of bromodeoxyuridine immunoreactive cells in the dentate gyrus were the same in the different groups. Our results suggest that the ketogenic diet does not disturb the neurogenesis in the rat dentate gyrus.
引用
收藏
页码：1235 / 1237
页数：3
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