Following evolution of bacterial antibiotic resistance in real time

被引：5
|
作者：
Rosenthal, Adam Z. [1 ]
Elowitz, Michael B. [1 ]
机构：
[1] CALTECH, Howard Hughes Med Inst, Div Biol, Pasadena, CA 91125 USA
来源：
NATURE GENETICS | 2012年 / 44卷 / 01期
关键词：
ESCHERICHIA-COLI; POPULATION;
D O I：
10.1038/ng.1048
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
A new study reports the development of the 'morbidostat', a device that allows for continuous culture of bacteria under a constant drug selection pressure using computer feedback control of antibiotic concentration. This device, together with bacterial whole-genome sequencing, allowed the authors to follow the evolution of resistance-conferring mutations in Escherichia coli populations in real time, providing support for deterministic evolution of resistance in some situations.
引用
收藏
页码：11 / 13
页数：3
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