Following evolution of bacterial antibiotic resistance in real time

被引：5

作者：

Rosenthal, Adam Z. ^{[1
]}

Elowitz, Michael B. ^{[1
]}

机构：

[1] CALTECH, Howard Hughes Med Inst, Div Biol, Pasadena, CA 91125 USA

来源：

NATURE GENETICS | 2012年 / 44卷 / 01期

关键词：

ESCHERICHIA-COLI; POPULATION;

D O I：

10.1038/ng.1048

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A new study reports the development of the 'morbidostat', a device that allows for continuous culture of bacteria under a constant drug selection pressure using computer feedback control of antibiotic concentration. This device, together with bacterial whole-genome sequencing, allowed the authors to follow the evolution of resistance-conferring mutations in Escherichia coli populations in real time, providing support for deterministic evolution of resistance in some situations.

引用

页码：11 / 13

页数：3

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