Cardiac allograft vasculopathy following fecal microbiota transplantation for recurrent C. difficile infection

被引：6

作者：

Barfuss, Spencer ^{[1
]}

Knackstedt, Elizabeth Doby ^{[2
]}

Jensen, Kyle ^{[2
]}

Molina, Kimberly ^{[2
]}

Lal, Ashwin ^{[2
]}

机构：

[1] Univ Utah, Primary Childrens Hosp, Pediat Residency Program, Salt Lake City, UT 84112 USA

[2] Univ Utah, Dept Pediat, Primary Childrens Hosp, Salt Lake City, UT USA

来源：

TRANSPLANT INFECTIOUS DISEASE | 2018年 / 20卷 / 06期

关键词：

cardiac allograft vasculopathy; CAV; clostridum difficile; fecal microbiota transplant; FMT; heart transplant;

D O I：

10.1111/tid.12983

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We report the case of a 3-year-old male who developed recurrent Clostridium difficile infection after receiving an orthotopic heart transplant. Despite multiple courses of antibiotics, C. difficile infection was persistent and he underwent a fecal microbiota transplant. The patient responded with resolution of his diarrhea. However, within 2 months he developed severe mixed rejection with high circulating donor-specific antibodies and significant coronary vasculopathy. Organ dysfunction led to the need for re-transplantation. The patient's postoperative course has since been complicated by pneumatosis intestinalis and recurrent C. difficile infection.

引用

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页数：4

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