Cardiac allograft vasculopathy following fecal microbiota transplantation for recurrent C. difficile infection

被引：6
|
作者：
Barfuss, Spencer [1 ]
Knackstedt, Elizabeth Doby [2 ]
Jensen, Kyle [2 ]
Molina, Kimberly [2 ]
Lal, Ashwin [2 ]
机构：
[1] Univ Utah, Primary Childrens Hosp, Pediat Residency Program, Salt Lake City, UT 84112 USA
[2] Univ Utah, Dept Pediat, Primary Childrens Hosp, Salt Lake City, UT USA
来源：
TRANSPLANT INFECTIOUS DISEASE | 2018年 / 20卷 / 06期
关键词：
cardiac allograft vasculopathy; CAV; clostridum difficile; fecal microbiota transplant; FMT; heart transplant;
D O I：
10.1111/tid.12983
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We report the case of a 3-year-old male who developed recurrent Clostridium difficile infection after receiving an orthotopic heart transplant. Despite multiple courses of antibiotics, C. difficile infection was persistent and he underwent a fecal microbiota transplant. The patient responded with resolution of his diarrhea. However, within 2 months he developed severe mixed rejection with high circulating donor-specific antibodies and significant coronary vasculopathy. Organ dysfunction led to the need for re-transplantation. The patient's postoperative course has since been complicated by pneumatosis intestinalis and recurrent C. difficile infection.
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