Hyperuricemia in psoriasis and psoriatic arthritis

Aim: Psoriasis is a common, chronic, disfiguring, inflammatory, non-infectious skin disorder associated with cardiovascular diseases, obesity, diabetes mellitus, hypertension, and hyperlipidemia. The association between psoriasis and hyperuricemia was also reported. Therefore, we aimed to evaluate serum uric acid levels in psoriasis and psoriatic arthritis (PsA) patients. Material and Methods: The study involved one hundred twenty (64 males and 56 females) patients, including 88 with psoriasis vulgaris and 32 with PsA, matched for age and sex with 120 healthy controls. Disease activity scores using Psoriasis Area Severity Index (PASI) score and Disease Activity Score using 28 joints (DAS28) were estimated for all patients. In addition, serum uric acid levels were measured for all the study participants. Results: Serum uric acid levels were 6.2 +/- 2.5 mg/dl and 4.1 +/- 1.2 mg/dl for psoriatic patients and controls, respectively. High serum uric acid levels were associated with high PASI scores and high DAS28 in psoriatic and PsA patients, respectively. Discussion: Psoriasis and PsA are significantly associated with hyperuricemia. Hyperuricemia is correlated to high PASI and high DAS28.