Recent Technologies for Genetic Code Expansion and their Implications on Synthetic Biology Applications

被引：19

作者：

Tang, Hongting ^{[1
]}

Zhang, Pan ^{[1
]}

Luo, Xiaozhou ^{[1
]}

机构：

[1] Chinese Acad Sci, Ctr Synthet Biochem, Shenzhen Inst Synthet Biol, Shenzhen Inst Adv Technol, Shenzhen 518055, Peoples R China

来源：

JOURNAL OF MOLECULAR BIOLOGY | 2022年 / 434卷 / 08期

基金：

国家重点研发计划;

关键词：

non-canonical amino acid biosynthesis; GCE optimization; synthetic parts; synthetic circuits; synthetic chassis; UNNATURAL AMINO-ACIDS; FREE PROTEIN-SYNTHESIS; SITE-SPECIFIC INCORPORATION; ESCHERICHIA-COLI; L-DIHYDROXYPHENYLALANINE; ORTHOGONAL TRANSLATION; CRYSTAL-STRUCTURE; LIGHT ACTIVATION; GENERAL-APPROACH; RNA;

D O I：

10.1016/j.jmb.2021.167382

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Genetic code expansion (GCE) enables the site-specific incorporation of non-canonical amino acids as novel building blocks for the investigation and manipulation of proteins. The advancement of genetic code expansion has been benefited from the development of synthetic biology, while genetic code expansion also helps to create more synthetic biology tools. In this review, we summarize recent advances in genetic code expansion brought by synthetic biology progresses, including engineering of the translation machinery, genome-wide codon reassignment, and the biosynthesis of non-canonical amino acids. We highlight the emerging application of this technology in construction of new synthetic biology parts, circuits, chassis, and products. (C) 2021 Published by Elsevier Ltd.

引用

页数：16

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