A novel imidazole derivate inhibits STAT3 activation via induction of SHP-1 hepatocellular carcinoma

被引：0
|
作者：
Su, Jung-Chen [1 ]
Wu, Szu-Hsien [1 ]
Chen, Kuen-Feng [2 ]
Tai, Wei-Tien [2 ]
Huang, Jui-Wen [3 ]
Shiau, Chung-Wai [1 ]
机构：
[1] Natl Yang Ming Univ, Taipei 112, Taiwan
[2] Natl Taiwan Univ Coll Med, Taipei, Taiwan
[3] Ind Technol Res Inst, Hsinchu, Taiwan
来源：
CANCER RESEARCH | 2014年 / 74卷 / 19期
关键词：
D O I：
10.1158/1538-7445.AM2014-3807
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
3807
引用
收藏
页数：1
相关论文
共 50 条
  • [11] Constitutive activation of STAT3 in Sézary syndrome is independent of SHP-1
    R C T McKenzie
    C L Jones
    I Tosi
    J A Caesar
    S J Whittaker
    T J Mitchell
    [J]. Leukemia, 2012, 26 : 323 - 331
  • [12] Leonurine ameliorates the STAT3 pathway through the upregulation of SHP-1 to retard the growth of hepatocellular carcinoma cells
    Jung, Young Yun
    Kim, Chulwon
    Shanmugam, Muthu K.
    Deivasigamani, Amudha
    Chinnathambi, Arunachalam
    Alharbi, Sulaiman Ali
    Rangappa, Kanchugarakoppal S.
    Hui, Kam Man
    Sethi, Gautam
    Mohan, Chakrabhavi Dhananjaya
    Ahn, Kwang Seok
    [J]. CELLULAR SIGNALLING, 2024, 114
  • [13] Guggulsterone, a Farnesoid X Receptor Antagonist, Inhibits Constitutive and Inducible STAT3 Activation through Induction of a Protein Tyrosine Phosphatase SHP-1
    Ahn, K. W.
    Sethi, G.
    Sung, B.
    Goel, A.
    Ralhan, R.
    Aggarwal, B. B.
    [J]. CANCER RESEARCH, 2018, 78 (17) : 5184 - 5184
  • [14] SHP-1 alleviates atrial fibrosis in atrial fibrillation by modulating STAT3 activation
    Zang, Xiaobiao
    Zhao, Zhihan
    Chen, Ke
    Song, Weifeng
    Ma, Jifang
    Fu, Haixia
    Wang, Xianqing
    Zhao, Yonghui
    [J]. EXPERIMENTAL BIOLOGY AND MEDICINE, 2023, 248 (11) : 979 - 990
  • [15] Euphorbiasteroid Induces Apoptosis as Well as Autophagy through Modulating SHP-1/STAT3 Pathway in Hepatocellular Carcinoma Cells
    Kim, Na Young
    Sethi, Gautam
    Um, Jae-Young
    Ahn, Kwang Seok
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (18)
  • [16] Ginkgetin Blocks Constitutive STAT3 Activation and Induces Apoptosis through Induction of SHP-1 and PTEN Tyrosine Phosphatases
    Baek, Seung Ho
    Lee, Jae Hwi
    Ko, Jeong-Hyeon
    Lee, Hanwool
    Nam, Dongwoo
    Lee, Seok Geun
    Yang, Woong Mo
    Um, Jae-Young
    Lee, Junhee
    Kim, Sung-Hoon
    Shim, Bum Sang
    Ahn, Kwang Seok
    [J]. PHYTOTHERAPY RESEARCH, 2016, 30 (04) : 567 - 576
  • [17] β-Caryophyllene Oxide Inhibits Constitutive and Inducible STAT3 Signaling Pathway Through Induction of the SHP-1 Protein Tyrosine Phosphatase
    Kim, Chulwon
    Cho, Somi K.
    Kapoor, Shweta
    Kumar, Ansu
    Vali, Shireen
    Abbasi, Taher
    Kim, Sung-Hoon
    Sethi, Gautam
    Ahn, Kwang Seok
    [J]. MOLECULAR CARCINOGENESIS, 2014, 53 (10) : 793 - 806
  • [18] Blockade of STAT3 activation by sorafenib derivatives through enhancing SHP-1 phosphatase activity
    Chen, Kuen-Feng
    Tai, Wei-Tien
    Hsu, Cheng-Yi
    Huang, Jui-Wen
    Liu, Chun-Yu
    Chen, Pei-Jer
    Kim, InKi
    Shiau, Chung-Wai
    [J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2012, 55 : 220 - 227
  • [19] A sorafenib derivative and novel SHP-1 agonist, SC-59, acts synergistically with radiotherapy in hepatocellular carcinoma cells through inhibition of STAT3
    Huang, C. Y.
    Tai, W. T.
    Hsieh, C. Y.
    Lai, Y. J.
    Hsu, W. M.
    Chen, L. J.
    Shiau, C. W.
    Chen, K. F.
    [J]. EUROPEAN JOURNAL OF CANCER, 2014, 50 : S174 - S174
  • [20] A sorafenib derivative and novel SHP-1 agonist, SC-59, acts synergistically with radiotherapy in hepatocellular carcinoma cells through inhibition of STAT3
    Huang, Chao-Yuan
    Tai, Wei-Tien
    Hsieh, Chi-Ying
    Hsu, Wan-Mai
    Lai, Ying-Jiun
    Chen, Li-Ju
    Shiau, Chung-Wai
    Chen, Kuen-Feng
    [J]. CANCER LETTERS, 2014, 349 (02) : 136 - 143
12345