Regression in primary cutaneous melanoma is not predictive for sentinel lymph node micrometastasis.

被引：6
|
作者：
Alquier-Bouffard, A.
Franck, F.
Joubert-Zakeyh, J.
Barthelemy, I.
Mansard, S.
Ughetto, S.
Ublet-Cuvelier, B. A.
Dechelotte, P.-J.
Mondie, J.-M.
Souteyrand, P.
D'Incan, M.
机构：
[1] Univ Auvergne Clermont Ferrand 1, CHU, Hotel Dieu, Serv Dermatol, Clermont Ferrand, France
[2] Univ Auvergne Clermont Ferrand 1, CHU, Hotel Dieu, Serv Anat Pathol, Clermont Ferrand, France
[3] Univ Auvergne Clermont Ferrand 1, CHU, Hotel Dieu, Serv Chirurg Maxillofaciale Plast & Reconstructri, Clermont Ferrand, France
[4] CHU, Hotel Dieu, Dept Biostat, Clermont Ferrand, France
来源：
ANNALES DE DERMATOLOGIE ET DE VENEREOLOGIE | 2007年 / 134卷 / 6-7期
关键词：
D O I：
10.1016/S0151-9638(07)89262-3
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Background. The predictive value of regression in melanoma is debated. Aim of the study. A retrospective single-centre study to evaluate the correlation between regression in primary skin tumor and the presence of micrometastases in sentinel lymph nodes. Patients and methods. Histological signs of regression in 84 melanomas (> 1 mm) with corresponding sentinel lymph nodes were studied by two independent pathologists. Results. Regression was seen in 40 skin melanoma tumors while micrometastasis was seen in 24. Of the tumors with micrometastasis, only 10 were regressive (RR: 0.47, P=0.49). Breslow value > 2 mm and male sex were predictive for node micrometastasis (RR: 4.6, P=0.03 and RR: 7.6, p =0.006, respectively). On multivariate analysis, these two factors were independent. Comments. These data suggest that regression in primary cutaneous melanoma is not predictive for lymph node metastasis.
引用
收藏
页码：521 / 525
页数：5
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