New malyngamides from the Hawaiian cyanobacterium Lyngbya majuscula

被引：47
|
作者：
Kan, Y [1 ]
Sakamoto, B
Fujita, T
Nagai, H
机构：
[1] Suntory Inst Bioorgan Res, Osaka 6188503, Japan
[2] Univ Hawaii Manoa, Dept Chem, Honolulu, HI 96822 USA
来源：
JOURNAL OF NATURAL PRODUCTS | 2000年 / 63卷 / 12期
关键词：
D O I：
10.1021/np000250t
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Isomalyngamides A and B (1, 2) were isolated and characterized from a collection of the cyanobacterium Lyngbya majuscula from Hawaiian waters. These compounds represent a new type of malyngamide, similar to malyngamides Q and R, in which the conformation of the chloromethylene group is opposite from the majority of previously reported malyngamides. The geometry of the chloromethylene moiety was elucidated from the long-range coupling constants ((3)J(C-H)) Obtained from editing-HETLOC and phase-sensitive HMBC experiments. Isomalyngamides A and B (1, 2) showed lethal toxicity to crayfish.
引用
收藏
页码：1599 / 1602
页数：4
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