Heterogeneous Genetic Location of mcr-1 in Colistin-Resistant Escherichia coli Isolates from Humans and Retail Chicken Meat in Switzerland: Emergence of mcr-1-Carrying IncK2 Plasmids

被引：56
|
作者：
Dona, Valentina [1 ,3 ]
Bernasconi, Odette J. [1 ,2 ]
Pires, Joao [1 ,2 ]
Collaud, Alexandra [3 ]
Overesch, Gudrun [3 ]
Ramette, Alban [1 ]
Perreten, Vincent [3 ]
Endimiani, Andrea [1 ]
机构：
[1] Univ Bern, Inst Infect Dis, Bern, Switzerland
[2] Univ Bern, Grad Sch Cellular & Biomed Sci, Bern, Switzerland
[3] Univ Bern, Vetsuisse Fac, Inst Vet Bacteriol, Bern, Switzerland
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2017年 / 61卷 / 11期
基金：
瑞士国家科学基金会;
关键词：
colistin; chromosome; E; coli; mcr-1; food; IncK2; Escherichia coli; animals; chromosome organization; humans; meat; plasmids; POULTRY MEAT; ENTEROBACTERIACEAE;
D O I：
10.1128/AAC.01245-17
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
We characterized the genetic environment of mcr-1 in colistin-resistant Escherichia coli strains isolated in Switzerland during 2014 to 2016 from humans (n = 3) and chicken meat (n = 6). Whole-genome and plasmid sequencing identified the mcr-1 gene integrated in IncX4 (of which, one strain carried the mcr-1.2 variant), IncI2, IncHI2, and novel IncK2 plasmids (overall, n = 7), as well as in the bacterial chromosome (n = 2) in single or duplicate copies. Our study supports the easy mobilization of mcr-1 across diverse genetic locations.
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页数：6
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