A Synthesis of Oseltamivir (Tamiflu) Starting from D-Mannitol

被引：44
|
作者：
Ko, Ji S. [1 ]
Keum, Ji E. [1 ]
Ko, Soo Y. [1 ]
机构：
[1] Ewha Womans Univ, Dept Chem, Seoul 120750, South Korea
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2010年 / 75卷 / 20期
关键词：
VARIABLE STRATEGY; PHOSPHATE TAMIFLU; INHIBITOR OSELTAMIVIR; ASYMMETRIC-SYNTHESIS; ACID; CARBASUGARS; RELATIVES; ACCESS; OXIDATION;
D O I：
10.1021/jo101517g
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A sythesis oseltamivir (Tamiflu) was achieved starting from D-mannitol A unique feature of the synthetic route is that an acyelic processor was constructed which was then cyclized in an ultramolecular aldol reaction to form the Tamiflu skeletion Throughout the synthesis well-established. highly efficient reactions were employed, and no protecion/deprotection sequence was needed
引用
收藏
页码：7006 / 7009
页数：4
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