Landanes and Sucrose Esters from Physalis sordida

Eight new compounds, labdanes 2-4, honmergostane 10, and sucrose esters 12-15, were isolated from aerial parts of Physalis sordida together with several known compounds. Structures of the new compounds were elucidated using spectroscopic evidence and chemical transformations. The structure of 10 was confirmed by X-ray crystallographic analysis of its methyl ester. Anti-inflammatory activity of compounds 1, 2, 4, 5, and 12-15 was evaluated using the TPA-induced mouse ear edema test. Compounds 12 (IC(50) 0.26 mu mol/ear) and 15 (IC(50) 0.24 mu mol/ear) showed anti-inflammatory activity similar to that of indomethacin (IC(50) 0.24 mu mol/ear).