Landanes and Sucrose Esters from Physalis sordida

被引：33
|
作者：
Perez-Castorena, Ana-L [1 ]
Martinez, Mahinda [2 ]
Maldonado, Emma [1 ]
机构：
[1] Univ Nacl Autonoma Mexico, Inst Quim, Coyoacan 04510, DF, Mexico
[2] Univ Autonoma Queretaro, Fac Ciencias Nat, Col Juriquilla 76230, Queretaro, Mexico
来源：
JOURNAL OF NATURAL PRODUCTS | 2010年 / 73卷 / 07期
关键词：
WITHANOLIDES; ANGULATA; FLAVONOIDS;
D O I：
10.1021/np100127k
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Eight new compounds, labdanes 2-4, honmergostane 10, and sucrose esters 12-15, were isolated from aerial parts of Physalis sordida together with several known compounds. Structures of the new compounds were elucidated using spectroscopic evidence and chemical transformations. The structure of 10 was confirmed by X-ray crystallographic analysis of its methyl ester. Anti-inflammatory activity of compounds 1, 2, 4, 5, and 12-15 was evaluated using the TPA-induced mouse ear edema test. Compounds 12 (IC(50) 0.26 mu mol/ear) and 15 (IC(50) 0.24 mu mol/ear) showed anti-inflammatory activity similar to that of indomethacin (IC(50) 0.24 mu mol/ear).
引用
收藏
页码：1271 / 1276
页数：6
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