A20, an inhibitor of cell death, self-associates by its zinc finger domain

被引：42
|
作者：
DeValck, D
Heyninck, K
VanCriekinge, W
Contreras, R
Beyaert, R
Fiers, W
机构：
[1] STATE UNIV GHENT,MOLEC BIOL LAB,B-9000 GHENT,BELGIUM
[2] FLANDERS INTERUNIV INST BIOTECHNOL,B-9000 GHENT,BELGIUM
来源：
FEBS LETTERS | 1996年 / 384卷 / 01期
关键词：
zinc finger protein; protein-protein interaction; self-association; apoptosis; necrosis; tumor necrosis factor;
D O I：
10.1016/0014-5793(96)00283-9
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A20 is a primary response gene which is induced after monocyte adherence or cytokine stimulation of a variety of cells, The A20 protein belongs to a novel class of Cys(2)/Cys(2) zinc finger proteins, and has been characterized as an inhibitor of both apoptotic and necrotic cell death. In order to clarify its molecular mechanism of action, we used the yeast-based two-hybrid system to screen for A20-associated proteins, Here we report that A20 is able to self-associate, and demonstrate that the latter interaction is mediated by its zinc finger domain.
引用
收藏
页码：61 / 64
页数：4
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