A20, an inhibitor of cell death, self-associates by its zinc finger domain

被引：42
|
作者：
DeValck, D
Heyninck, K
VanCriekinge, W
Contreras, R
Beyaert, R
Fiers, W
机构：
[1] STATE UNIV GHENT,MOLEC BIOL LAB,B-9000 GHENT,BELGIUM
[2] FLANDERS INTERUNIV INST BIOTECHNOL,B-9000 GHENT,BELGIUM
来源：
FEBS LETTERS | 1996年 / 384卷 / 01期
关键词：
zinc finger protein; protein-protein interaction; self-association; apoptosis; necrosis; tumor necrosis factor;
D O I：
10.1016/0014-5793(96)00283-9
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A20 is a primary response gene which is induced after monocyte adherence or cytokine stimulation of a variety of cells, The A20 protein belongs to a novel class of Cys(2)/Cys(2) zinc finger proteins, and has been characterized as an inhibitor of both apoptotic and necrotic cell death. In order to clarify its molecular mechanism of action, we used the yeast-based two-hybrid system to screen for A20-associated proteins, Here we report that A20 is able to self-associate, and demonstrate that the latter interaction is mediated by its zinc finger domain.
引用
收藏
页码：61 / 64
页数：4
相关论文
共 50 条
  • [1] ROLE OF A20, A NOVEL ZINC-FINGER PROTEIN IN PROGRAMMED CELL-DEATH
    DIXIT, VM
    FASEB JOURNAL, 1994, 8 (05): : A807 - A807
  • [2] Inhibition of Tumor Necrosis Factor-induced necrotic cell death by the zinc finger protein A20
    Heyninck, K
    Denecker, G
    De Valck, D
    Fiers, W
    Beyaert, R
    ANTICANCER RESEARCH, 1999, 19 (4B) : 2863 - 2868
  • [3] Arrestin1 self-associates to prevent cell death induced by the cytotoxic monomer
    Gurevich, Vsevolod V.
    Song, Xiufeng
    Vishnivetskiy, Sergey A.
    Kim, Miyeon
    Hanson, Susan M.
    Hubbell, Wayne L.
    Chen, Jeannie
    Gurevich, Eugenia V.
    FASEB JOURNAL, 2010, 24
  • [4] The RhoGEF protein Plekhg5 self-associates via its PH domain to regulate apical cell constriction
    Popov, Ivan K.
    Tao, Jiahui
    Chang, Chenbei
    MOLECULAR BIOLOGY OF THE CELL, 2024, 35 (10) : 1 - 13
  • [5] IR Spectra of Trifluoromethanesulfonamide and Its Self-Associates in the Gas Phase
    N. N. Chipanina
    L. V. Sherstyannikova
    Yu. S. Danilevich
    V. K. Turchaninov
    B. A. Shainyan
    Russian Journal of General Chemistry, 2004, 74 : 582 - 585
  • [6] IR spectra of trifluoromethanesulfonamide and its self-associates in the gas phase
    Chipanina, NN
    Sherstyannikova, LV
    Danilevich, YS
    Turchaninov, VK
    Shainyan, BA
    RUSSIAN JOURNAL OF GENERAL CHEMISTRY, 2004, 74 (04) : 582 - 585
  • [7] LYMPHOID EXPRESSION AND REGULATION OF A20, AN INHIBITOR OF PROGRAMMED CELL-DEATH
    TEWARI, M
    WOLF, FW
    SELDIN, MF
    OSHEA, KS
    DIXIT, VM
    TURKA, LA
    JOURNAL OF IMMUNOLOGY, 1995, 154 (04): : 1699 - 1706
  • [8] THE A20 ZINC-FINGER PROTEIN-INDUCED BY TNF-ALPHA AND VIRUSES INHIBITS PROGRAMMED CELL-DEATH
    OPIPARI, AW
    LAHERTY, CD
    KRIKOS, A
    DIXIT, VM
    FASEB JOURNAL, 1992, 6 (05): : A1780 - A1780
  • [9] The human serpin proteinase inhibitor-9 self-associates at physiological temperatures
    Benning, LN
    Whisstock, JC
    Sun, JR
    Bird, PI
    Bottomley, SP
    PROTEIN SCIENCE, 2004, 13 (07) : 1859 - 1864
  • [10] Zinc finger protein A20 is involved in the antipsoriatic effect of calcipotriol
    Liu, X.
    Liu, Y.
    Xu, M.
    Li, J.
    Teng, X.
    Cheng, H.
    Xia, Y.
    BRITISH JOURNAL OF DERMATOLOGY, 2016, 175 (02) : 314 - 324
12345