Synthesis of vitamin E analogues: Possible active forms of vitamin E

被引：3
|
作者：
Fujishima, T
Kagechika, H
Shudo, K
机构：
[1] Faculty of Pharmaceutical Sciences, University of Tokyo, Bunkyo-ku, Tokyo 113
来源：
ARCHIV DER PHARMAZIE | 1996年 / 329卷 / 01期
关键词：
vitamin E; tocopherol; antioxidant activity;
D O I：
10.1002/ardp.19963290106
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
We synthesized several vitamin E analogues containing oxygenated functional groups in place of the 8-methyl group which is common to all the natural vitamin E congeners, based on the hypothesis that the methyl group might have specific functions other than the antioxidant function. All the vitamin E analogues examined has antioxidant activity. 8-[6-Hydroxy-2,5,7-trimethyl-2-(4,8,12-trimethyltridecanyl)chroman]methanol (1d) and 2,5,7-trimethyl-2-(4,8,12-trimethyltridecanyl)chroman-6-ol (4d) showed similar activity to alpha-tocopherol. 6-Hydroxy-2,5,7-trimethyl-2-(4,8,12-trimethyltridecanyl)chroman-8-carbaldehyde (2d) and 6-hydroxy-2,5,7-trimethyl-2-(4,8,12-trimethyltridecanyl)chroman-8-carboxylic acid (3d) showed weaker activity than alpha-tocopherol, but their duration of action, especially that of 3d was considerably longer.
引用
收藏
页码：27 / 34
页数：8
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