Novel DNA-Damaging tropolone derivatives from Goupia glabra

被引：30
|
作者：
Mesa-Siverio, D
Estévez-Braun, A
Ravelo, AG
Murguia, JR
Rodríguez-Afonso, A
机构：
[1] Inst Univ Bioorgan Antonio Gonzalez Gonzalez, Tenerife 38206, Spain
[2] Inst Canario Invest Canc, Tenerife 38206, Spain
[3] Hosp Univ Canarias, Unidad Invest, Tenerife 38320, Spain
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2003年 / 2003卷 / 21期
关键词：
benzotropolone; cycloadditions; DNA damage; natural products;
D O I：
10.1002/ejoc.200300284
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Two novel tropolone derivatives 1 and 2 have been isolated from Goupia glabra. Their structures were determined by extensive 1D and 2D NMR spectroscopic studies. Compound 2 constitutes the first example isolated from a natural source of a Diels-Alder adduct between a tropolone and a naphthalene derivative. Compounds 1 and 2 exhibit significant toxicity towards a panel of DNA damage checkpoint defective yeast mutants, and behave as genotoxins, which highlights their potential to be used as anticancer drugs. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003).
引用
收藏
页码：4243 / 4247
页数：5
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