Direct organocatalytic α-fluorination of aldehydes and ketones

被引：176
|
作者：
Enders, D [1 ]
Hüttl, MRM [1 ]
机构：
[1] Rhein Westfal TH Aachen, Inst Organ Chem, D-52074 Aachen, Germany
来源：
SYNLETT | 2005年 / 06期
关键词：
organocatalysis; Selectfluor; electrophilic fluorination; aldehydes; ketones;
D O I：
10.1055/s-2005-864813
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The first organocatalytic direct alpha-fluorination of aldehydes and ketones employing Selectfluor {1-chloromethyl-4-fluoro- 1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate)} as the fluorine source is reported. (S)-Proline and related derivatives act as organocatalysts to give the corresponding alpha-fluoroaldehydes and alpha-fluoroketones in moderate to good yields (47-78%). The asymmetric inductions are still low (ee <= 36%).
引用
收藏
页码：991 / 993
页数：3
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