Regioselective C-H Activation and Sequential C-C and C-O Bond Formation Reactions of Aryl Ketones Promoted by an Yttrium Carbene

被引：98
|
作者：
Mills, David P. [1 ]
Soutar, Lyndsay [1 ]
Lewis, William [1 ]
Blake, Alexander J. [1 ]
Liddle, Stephen T. [1 ]
机构：
[1] Univ Nottingham, Sch Chem, Nottingham NG7 2RD, England
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2010年 / 132卷 / 41期
基金：
英国工程与自然科学研究理事会;
关键词：
METAL-CARBON BONDS; STRUCTURAL-CHARACTERIZATION; ALKYLIDENE COMPLEXES; CALCIUM CARBENE; REACTIVITY; METHYLIDENE; LANTHANIDES; MONOXIDE; DIANION; SYSTEM;
D O I：
10.1021/ja107958u
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Rare earth carbenes exclusively exhibit Wittig-type reactivity with carbonyl compounds to afford alkenes. Here, we report that yttrium carbenes can effect regioselective ortho-C-H activation and sequential C-C and C-O bond formation reactions of aryl ketones to give iso-benzofurans and hydroxymethylbenzophenones. With MeCOPh, cyclotetramerization occurs giving a substituted cyclohexene. This demonstrates new rare earth carbene reactivity which complements existing Wittig-type reactivity.
引用
收藏
页码：14379 / 14381
页数：3
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