Efficient synthesis of 6-amino-substituted pyridin-2(1H)-ones using in situ generated propiolic acid chloride

被引：20
|
作者：
Schirok, H [1 ]
Alonso-Alija, C [1 ]
Michels, M [1 ]
机构：
[1] Bayer HealthCare, Pharma Res, D-42096 Wuppertal, Germany
来源：
SYNTHESIS-STUTTGART | 2005年 / 18期
关键词：
pyridin-2(1H)-ones; cyclizations; thioacetals; N; S-acetals; ring closure;
D O I：
10.1055/s-2005-872217
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A regioselective and highly efficient synthesis of 6-amino-substituted pyridin-2(1H)-ones is presented. In situ generated propiolic acid chloride was used for the cyclization of acyclic beta-keto N,S-acetals to afford the heterocyclic core. Substitution by amines led to a flexible access of the target compounds.
引用
收藏
页码：3085 / 3094
页数：10
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