Vilsmeier Reaction of Enaminones: Efficient Synthesis of Halogenated Pyridin-2(1H)-ones

被引：57
|
作者：
Zhang, Rui [1 ]
Zhang, Dingyuan [1 ]
Guo, Yongli [1 ]
Zhou, Guangyuan [1 ]
Jiang, Zijiang [1 ]
Dong, Dewen [1 ]
机构：
[1] Chinese Acad Sci, Changchun Inst Appl Chem, Changchun 130022, Peoples R China
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2008年 / 73卷 / 23期
基金：
中国国家自然科学基金;
关键词：
D O I：
10.1021/jo801959j
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A facile and efficient one-pot synthesis of halogenated pyridin-2(1H)-ones from a series of readily available enaminones under Vilsmeier conditions is described, and a mechanism involving sequential halogenation, formylation, and intramolecular nucleophilic cyclization is proposed.
引用
收藏
页码：9504 / 9507
页数：4
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