Interleukin-8 stimulates human immunodeficiency virus type 1 replication and is a potential new target for antiretroviral therapy

被引:115
|
作者
Lane, BR
Lore, K
Bock, PJ
Andersson, J
Coffey, MJ
Strieter, RM
Markovitz, DM
机构
[1] Univ Michigan, Med Ctr, Div Infect Dis, Ann Arbor, MI 48109 USA
[2] Univ Michigan, Med Ctr, Div Pulm & Crit Care Med, Ann Arbor, MI 48109 USA
[3] Univ Michigan, Med Ctr, Dept Internal Med, Ann Arbor, MI 48109 USA
[4] Univ Michigan, Med Ctr, Grad Program Cellular & Mol Biol, Ann Arbor, MI 48109 USA
[5] Karolinska Inst, Dept Microbiol Pathol & Immunol, Stockholm, Sweden
[6] Karolinska Inst, Dept Med, Ctr Infect Dis, Stockholm, Sweden
关键词
D O I
10.1128/JVI.75.17.8195-8202.2001
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Production of the C-X-C chemokines interleukin-8 (IL-8) and growth-regulated oncogene alpha (GRO-alpha) in macrophages is stimulated by exposure to human immunodeficiency virus type 1 (HIV-1). We have demonstrated previously that GRO-a then stimulates HIV-1 replication in both T lymphocytes and macrophages. Here we demonstrate that IL-8 also stimulates HIV-1 replication in macrophages and T lymphocytes. We further show that increased levels of IL-8 are present in the lymphoid tissue of patients with AIDS. In addition, we demonstrate that compounds which inhibit the actions of IL-8 and GRO-a via their receptors, CXCR1 and CXCR2, also inhibit HIV-1 replication in both T lymphocytes and macrophages, indicating potential therapeutic uses for these compounds in HIV-1 infection and AIDS.
引用
收藏
页码:8195 / 8202
页数:8
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